Genetic Variability of Tumor Necrosis Factor Receptors Type I and II in Lymphoproliferative Diseases in the Serbian Population –
Summary TNF-alpha and LT-alpha are involved in the pathogenesis of established lymphoproliferative diseases. Both molecules bind to TNFRI and TNFRII. TNFRI is the major mediator of the TNF pro-apoptotic and proliferative effects and TNFRII might enhance these effects. TNF receptors I and II are normally present on hematopoetic cells. TNFR II is cha...
By Tatjana Jevtović-Stoimenov, Danica Marković, Milena Despotović, Dušica Pavlović, Gordana Kocić
Catalase C-262T Gene Variant in Patients with Bronchial Asthma
Summary Bronchial asthma (BA) is a chronic inflammatory disease of the airways in the pathogenesis of which oxidative stress has a very important role. Single nucleotide polymorphisms (SNPs) in catalase gene may result in decreased antioxidative defense capacity, and thus a higher risk for BA development. Since oxidative stress has an important rol...
By Milena Despotović, Tatjana Jevtović Stoimenov, Ivana Stanković, Jelena Bašić, Branka Đorđević, Dušica Pavlović