Introduction/Aim. Chronic apical periodontitis represents dynamic continuation of the presence of endodontic infection in the root canal system of the tooth, when the innate and acquired immune responses are activated and various cells and inflammatory mediators are recruited, which cause the consequent destruction of periapical tissues and the dev...

By Jelena Popović, Tatjana Cvetković, Tanja Džopalić, Aleksandar Mitić, Marija Nikolić, Radomir Barac, Nenad Stošić, Antonije Stanković

One of the primary goals in endodontics is efficient cleaning and shaping of the root canal while maintaining its original configuration. Numerous studies highlight the advantage of using nickel-titanium instruments and the most important is their high flexibility and the ability to penetrate the curved canals. The aim of this study was to analyze ...

By Nenad Stošić, Jelena Popović, Marija Anđelković-Apostolović, Aleksandar Mitić, Marija Nikolić, Radomir Barac

Summary Host response to antigen stimulation in chronic inflammatory periapical lesions is mainly controlled by the balance between proinflammatory and anti-inflammatory cytokines. The aim of this study was to determine the concentration of TGF-β1 in the tissue homogenates of periapical lesions and to analyse its level in relation to the sympto...

By Jelena Popović, Tatjana Cvetković, Tanja Džopalić, Aleksandar Mitić, Marija Nikolić, Radomir Barac

SUMMARY The aim of the paper was to investigate the tissue response to the implantation of "Endomethasone" (Septodont) in artificially prepared defect in the rat mandible. Sixteen Wistar male rats were used for the experiment. After anesthesia, a defect between the midline and the mental foramen of the left mandible was made (diameter 1.4...

By Marija Nikolić, Jovanka Gašić, Aleksandar Mitić, Jelena Popović, Aleksandra Radovanović, Radomir Barac