Nine Hypericum species (H. barbatum, H. hirsutum, H. linarioides, H. olympicum, H. perforatum, H. rochelii, H. rumeliacum, H. tetrapterum and H. umbellatum) collected in Serbia were assayed for inhibitory potential against xanthine oxidase in vitro, on the commercial enzyme, and compared with allopurinol. Seven studied Hypericum species (H. barbatum, H. rochelii, H. rumeliacum, H. umbellatum, H. perforatum, H. tetrapterum and H. olympicum) inhibit commercial xanthine oxidase with an IC50 below 100 μg/mL. H. barbatum exerted the most potent inhibitory effect (IC50 = 31.84 ± 6.64 μg/mL), followed closely by H. perforatum (IC50 = 37.12 ± 4.06 μg/mL).
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
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Nuraniye Eruygur, Esra Uçar, Burak Tüzün, Mehmet Ataş, Merve İnanır, Ahmet Demirbaş, Halil Bal, Belgin Coşge Şenkal, Tansu Uskutoğlu
(2024)
Evaluation of antioxidant, antimicrobial, enzyme inhibition activity, and cell viability capacity of Hypericum heterophyllum vent., an endemic species in Turkey's Flora
Journal of Molecular Structure, 1307()
10.1016/j.molstruc.2024.137908The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.