Background. Necrotizing soft tissue infections are actually the diseases with a severe outcome characterized by the progression of soft tissue inflammation with a catastrophic prognosis and the risk of major functional consequences. Only prompt diagnosis and prompt care, including prompt administration of appropriate antibiotic therapy and surgical treatment, can improve the outcome. Case report. A female patient, aged 66 years, came due to swelling and pain in the perineum. Before admission, the pains were of low intensity, and immediately before admission, their intensity increased. An incision was made in the perineal region and the abdominal region on the left. During the preparation, we came across a necrotic tissue from which a dark-gray liquid flew that had a strong smell. From the tenth postoperative day, secondary sutures were partly placed. Conclusion. Mortality and morbidity in this disease are high. A potential new treatment for this disease may be an antigen-inhibiting vaccine.
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