Acute myocardial infarction is the leading cause of premature morbidity and premature death worldwide. The aim of the paper was to determine the trends of acute myocardial infarction in the period between 2006 and 2019 in the population of the Nišava District. A descriptive study was performed. Data about acute myocardial infarction incidence and mortality were obtained from the population registry for Acute Coronary Syndrome of Serbia. Crude, specific and age-standardized incidence and mortality rates per 100,000 persons were calculated as well as the trend lines. A total number of 12,142 new cases of acute myocardial infarction (7,595 in males and 4,547 in females) were registered. Men suffered 1.7 times more often than females. An insignificantly decreasing acute myocardial infarction incidence trend y = 0.4868x + 112.24, R² = 0.0029 was recorded. A total of 3,925 persons died (2,260 males and 1,665 females). Men died 1.4 times more often than women and a significant decreasing mortality trend was recorded both males (y = -1.6112x + 52.563, R² = 0.7779) and in females (y = -0.4956x + 22.81, R² = 0.3306). A significant increasing mortality trend of acute myocardial infarction by age was determined y = 11.152x - 34.519, R² = 0.7022. The trend of incidence tended to decrease however, without statistical significance, but insignificantly. The incidence and mortality rates were higher in men than in women for the whole observed period. Mortality trend significantly decreased both in men and in women and significantly increased with age.
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