In many physiological processes, peptides play a critical role as neurotransmitters, hormones, antibiotics, etc. They have research importance in fields such as immunology, pharmacology, neuroscience and cell biology. There are many approaches for immunotherapies: some of them use the peptides as important components of chimeric molecules for immunosuppression, the others - as peptide-based vaccines for immunostimulation. These immunotherapeutic strategies offer the advantages of being safe, easy to produce, devoid of oncogenic potential, and can be chemically or genetically engineered into defined conformational active form. The peptides contain very important functional part called epitope, which is recognized by the immune system, specifically by antibodies, B or T cell receptors. Epitopes play a prominent role in the peptide-based vaccines and disease diagnosis. Protein-engineered or genetically engineered peptides conjugated to antibody-carrier could be used as a targeting device delivering the epitopes to the cells of interest.
Živković S. Dentin adhezivna sredstva u stomatologiji. Data status, Beograd. 2007;39–45.
2.
Stojanac I, Drobac M, Lj P, Stojšin I. Ispitivanje mikropropustljivosti savremenih sistema u dentinskim kavitetima. Med Preg. 2009;(7–8):295–303.
3.
Prati C, Teutonico S, Breschi A, Marchionni L, Savarino S, Mazzott L, et al. Artificial marginal caries after the use of self etching and total etching bonding system. J Dent Res. 2002;250.
4.
Prati C, Chersoni S, Suppa P, Breschi L. Resistance of marginal enamel to acid solubility is influenced by restorative systems: an in vitro scanning electron microscopic study. Clin Oral Invest. 2003;86–91.
5.
Dačić S, Dačić-Simonović D, Radičević G. Otpornost kondicionirane gleđi na dejstvo kariogenih rastvora. Srp Arh Celok Lek. 2008;(7–8):361–6.
6.
Dačić S, Dačić-Simonović D, Živković S, Radičević G, Mitić A, Stanojević I, et al. SEM analiza kvaliteta ivičnog pripoja kompozitnih ispuna za gleđ posle primene totalno nagrizajućeg i samonagrizajućeg adhezivnog sistema. Srp Arh Celok Lek. 2009;(9–10):475–81.
7.
Wilson N, Setcos J, Brunton P. Replacement or repair of dental restoration in. Challenges of the Future Chicago Quintessence Publishing. 2001;105–15.
8.
Van Meerbeek B, Munck J, Yoshida Y. Buonocore memorial lecture. Adhesion to enamel and dentin: current status and future challenges. Oper Dent. 2003;(3):215–35.
9.
Van Meerbeek B, Vargas S, Inoue S, Yoshida Y, Peumans M, Labrechts P, et al. Adhesives and cements to promote preservation dentistry. Operative Dentistry. 2001;119–44.
10.
Van Meerbeek B, Yoshida Y, Inoue S, Fukunda R, Okazaki M, Lambrechts P, et al. Interfacial characterization of resin-modified glass-ionomers to dentin. J Dental Res. 2001;1701–39.
11.
Dačić-Simonović D, Gašić J. Smear layer -uticaj na mikroproticanje i propustljivost dentina. Acta Stom Naissi. 2002;(38):35–9.
12.
Roulet J, Reich T, Blunck U, Noack M. Quantitative margin analysis in the scanning electron microscope. Scanning Microsc. 1989;(1):158–9.
13.
Tyas M, Burrow M. Adhesive restorative materials: A review. Australian Dental J. 2004;(3):112–21.
14.
Swift E, Perdigao J, Ho H. Bonding to enamel and dentin. A brief history and state of art. Quintessence International. 1995;(2):95–110.
15.
Yoshida Y, Van Meerbeek B, Nakayama Y, Snauweart J, Hellemans L, Lambrechts P, et al. Evidence of chemical bonding at biomaterial-hard tissue interfaces. Journal of Dental Research. 2000;(2):709–14.
16.
Tay F, Gwinnett A, Pang K, Wei S. Resin permeation into acid-conditioned, moist and dry dentin: A paradigm using water-free adhesive primers. Journal of Dental Research. 1996;(4):1034–44.
17.
Frankenberger R, Franklin R. Self-etch vs etch-andrinse adhesives: effect of thermo-mechanical fatigue loading on marginal quality of bonded resin composite restorations. Dent Mater. 2005;397–412.
18.
Perdigao J, Geraldini S. Bonding characteristics of self etching adhesives to intact versus prepared enamel. J Esthet Rest Dent. 2003;32–41.
19.
Miyazaki M, Hinoura K, Honjo G, Onose H. Effect of self-etching primer applicacion method on enamel bond strenght. Am J Dent. 2002;(6):412–6.
20.
Haak R, Wicht M, Noack M. Marginal and internal adaptation of extended class I restoration lined with flowable composites. J Dentistry. 2003;231–9.
21.
Chuang S, Jin Y, Lui J, Chang C, Chang D. Influence of flowable composite lining thickness on Class II composite restorations. Oper Dent. 2004;(3):301–8.
22.
Inoue S, Van-Meerbeek B, Abe Y, Yoshida Y, Lambrechts P, Vanherle G, et al. Effect of remaining dentin thickness and the use of conditioner on microtensile bond strength of glass -ionomer adhesive. Dental Materials. 2001;(5):445–55.
23.
Mount G, Hume W. Preservation and restoration of tooth structure. 1998;55–107.
24.
Carvelho R, Peretra J, Yoshiyama M, Dh P. A review of polymerisation contraction: the influence of stress development versus stress relief. Oper Dent. 1996;(1):17–24.
25.
Dačić S. Ispitivanje otpornosti marginalne gleđi na kariogeni rastvor u zavisnosti od restaurativnih sistema kaviteta V klase. (Magistarska teza) Univerzitet u Nišu. 2007;5–70.
26.
Vulićević Z. Klinička primena materijala u dečjoj stomatologiji. 2010;137–84.
27.
Arends J, Christofferson J. The nature of early caries lesion in enamel. J Dent Res. 1986;2–11.
28.
Christensen G. The need for caries preventive restorative materials. JADA. 2000;1347–9.
29.
Feilzer A, Gee D, Davidson A, C. Setting stress in composite resin in relation to configuration of the restoration. J Dent Res. 1987;1636–9.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
