In vitro assessment of the lipid peroxidation of N,N'-disubstituted benzimidazole-2-thiones: Hydrazides vs esters
Introduction: Oxidative stress and resulting lipid peroxidation are involved in numerous pathological conditions. For this reason, the role of antioxidants attracts attention and the radical-scavenging capacity of many natural and synthetic supplements and drugs has been extensively evaluated. Material and methods: In the present study, seven N,N'-...
By Jelena Lazarević, Jelena Zvezdanović, Neda Anastassova, Anelia Mavrova, Denitsa Yancheva, Andrija Šmelcerović
In vitro antioxidant properties of 2-imino-benzimidazole and 1,3-thiazolo[3,2-a]benzimidazolone derivatives
Antioxidant properties of 2-[2-imino-5-nitro-3-(2-oxo-2-phenylethyl)-2,3-dihydro-1H-benzimidazol1-yl]-1-phenylethanone (compound 1) and 2-(4-fluorobenzylidene)-6-(phenylcarbonyl)[1,3]thiazolo[3,2a]benzimidazol-3(2H)-one (compound 2) were evaluated in vitro. Compounds 1 and 2 did not show significant radical scavenging activity. It has been suggeste...
By Katarina Tomović, Jelena Mrmošanin, Denitsa Yancheva, Anelia Mavrova, Andrija Šmelcerović
Secondary Metabolites of Hypericum L. Species as Xanthine Oxidase Inhibitors
Summary Nine Hypericum species (H. barbatum, H. hirsutum, H. linarioides, H. olympicum, H. perforatum, H. rochelii, H. rumeliacum, H. tetrapterum and H. umbellatum) collected in Serbia were assayed for inhibitory potential against xanthine oxidase in vitro, on the commercial enzyme, and compared with allopurinol. Seven studied Hypericum species (H....
By Andrija Šmelcerović, Žaklina Šmelcerović, Katarina Tomović, Gordana Kocić, Aleksandra Đorđević