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The dissolution test is a simple and important in vitro method for assessing the bioequivalence, which aims to compare the bioavailability of generic and branded drugs. It implies the use of a proper apparatus (usually pharmacopoeially defined) in which the dosage form is dissolved, and the dissolution process itself is monitored/quantified using a...

By Ana Marković, Miroslava Spasić, Vesna Savić, Slavica Sunarić, Marija Tasić-Kostov

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By Ivana Nešić, Vesna Savić, Ana Kolarević

SUMMARY Clindamycin is an antibiotic effective against Gram-positive aerobes and both Gramnegative and Gram-positive anaerobic pathogens. Clindamycin (its phosphate ester) was used as a model drug for our study in order to check the efficacy of the developed vaginal gel formulations. The aim of this study was to develop an analytical metho...

By Milica Stanković, Vesna Savić, Valentina Marinković

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By Milica Stanković, Vesna Savić, Valentina Marinković