Role of Vitamin D as an Anti-Proliferative Compound on Prostate Cancer

Abstract

Summary The reason of prostate cancer is the mutation in the prostate cell. The present study was aimed at determining the effects of different concentrations of vitamin D on the anti-proliferative action of 24,25(OH)2D3 applied on LNCaP (cell line of human prostate cancer) cells. It was evident from the results that vitamin D having concentrations of 10-9nM showed the best anti-proliferative action on prostate cancer cells (LNCaP cells) compared to other concentrations used. Most of the receptors were expressed at 10-9nM resulting clear band in agarose gel image. Results also revealed that both nVDR and AR receptors (androgen receptors) were expressed well when treated with 10-9nM and 10-10nM concentrations of 24,25(OH)2D3. These findings confirm the potential use of vitamin D as an anti-proliferative compound against prostate cancer cells.

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