×
Home Current Archive Editorial board
News Contact
Research paper

Investigation of possible effects of Exendin-4 during exposure to mild chronic stress on dehydroepiandrosterone-induced polycystic ovary syndrome in rats

By
Burcu Köksal ,
Burcu Köksal
Sedat Yildiz ,
Sedat Yildiz
Tugba Ozgöcer ,
Tugba Ozgöcer
Azibe Yildiz ,
Azibe Yildiz
Nigar Vardi ,
Nigar Vardi
Özlem Barutcu
Özlem Barutcu

Abstract

References

1.
Marin MT, Cruz FC, Planeta CS. Chronic restraint or variable stresses differently affect the behavior, corticosterone secretion and body weight in rats. Physiology & Behavior. 2007;90(1):29–35.
2.
Smith C. Using Rodent Models to Simulate Stress of Physiologically Relevant Severity: When, Why and How. Glucocorticoids - New Recognition of Our Familiar Friend.
3.
McDougall SJ, Paull JRA, Widdop RE, Lawrence AJ. Restraint Stress. Hypertension. 2000;35(1):126–9.
4.
Sun L, Ji C, Jin L, Bi Y, Feng W, Li P, et al. Effects of Exenatide on Metabolie Changes, Sexual Hormones, Inflammatory Cytokines, Adipokines, and Weight Change in a DHEA-Treated Rat Model. Reproductive Sciences. 2016;23(9):1242–9.
5.
Conway G, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Franks S, Gambineri A, et al. The polycystic ovary syndrome: a position statement from the European Society of Endocrinology. European Journal of Endocrinology. 2014;171(4):P1–29.
6.
Hala MA, Magbolah SH. Effect of feeding on diets supplemented by some vegetable oils on blood lipids and bone mineral content in osteoporotic rats. Life Science Journal. 2013;10:1.
7.
Gokcel A, Baltali M, Tarim E, Bagis T, Gumurdulu Y, Karakose H, et al. Detection of insulin resistance in Turkish adults: a hospital‐based study. Diabetes, Obesity and Metabolism. 2003;5(2):126–30.
8.
İlk B. The Relationship Between Hepatosteatosis And Insulin Directors In Normal Glucose Tolerance Obeses. 2006.
9.
Iwasa T, Matsuzaki T, Tungalagsuvd A. Effects of chronic DHEA treatment on central and peripheral reproductive parameters, the onset of vaginal opening and the estrous cycle in female rats. Gynecol Endocrinol. 2016;28:1–4.
10.
Szayna M, Doyle ME, Betkey JA, Holloway HW, Spencer RGS, Greig NH, et al. Exendin-4 Decelerates Food Intake, Weight Gain, and Fat Deposition in Zucker Rats. Endocrinology. 2000;141(6):1936–41.
11.
DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD. Effects of Exenatide (Exendin-4) on Glycemic Control and Weight Over 30 Weeks in Metformin-Treated Patients With Type 2 Diabetes. Diabetes Care. 2005;28(5):1092–100.
12.
Torres SJ, Nowson CA. Relationship between stress, eating behavior, and obesity. Nutrition. 2007;23(11–12):887–94.
13.
Hinkle DE, Wiersma W, Jurs SG. Applied Statistics for the Behavioral Sciences. 2003.
14.
Shah ZA, Sharma P, Vohora SB. Ginkgo biloba normalises stress-elevated alterations in brain catecholamines, serotonin and plasma corticosterone levels. European Neuropsychopharmacology. 2003;13(5):321–5.
15.
Sternberg EM. Neural-immune interactions in health and disease. Journal of Clinical Investigation. 1997;100(11):2641–7.
16.
Rosmond R. Stress induced disturbances of the HPA axis: a pathway to type 2 diabetes Med Sci Monit Basic Res. 2003;9:35–9.
17.
Raison CL, Miller AH. When Not Enough Is Too Much: The Role of Insufficient Glucocorticoid Signaling in the Pathophysiology of Stress-Related Disorders. American Journal of Psychiatry. 2003;160(9):1554–65.
18.
Black PH, Garbutt LD. Stress, inflammation and cardiovascular disease. Journal of Psychosomatic Research. 2002;52(1):1–23.
19.
Kyrou I, Tsigos C. Chronic stress, visceral obesity and gonadal dysfunction. Hormones. 2008;7(4):287–93.
20.
Ralph CR, Lehman MN, Goodman RL, Tilbrook AJ. Impact of psychosocial stress on gonadotrophins and sexual behaviour in females: role for cortisol? Reproduction. 2016;152(1):R1–14.
21.
Kala M, Nivsarkar M. Role of cortisol and superoxide dismutase in psychological stress induced anovulation. General and Comparative Endocrinology. 2016;225:117–24.
22.
Lee M, Anderson E, Lee GY. Changes in ovarian morphology and serum hormones in the rat after treatment with dehydroepiandrosterone. The Anatomical Record. 1991;231(2):185–92.
23.
Singh P, Srivastava RK, Krishna A. Effects of gonadotropin-releasing hormone agonist and antagonist on ovarian activity in a mouse model for polycystic ovary. The Journal of Steroid Biochemistry and Molecular Biology. 2016;163:35–44.
24.
Lebbi I, Ben Temime R, Fadhlaoui A, Feki A. Ovarian Drilling in PCOS: Is it Really Useful? Frontiers in Surgery. 2.
25.
Fauser BCJM, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS). Human Reproduction. 2012;27(1):14–24.
26.
Talbott EO, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ. Polycystic Ovarian Syndrome (PCOS): A Significant Contributor to The Overall Burden of Type 2 Diabetes in Women. Journal of Women’s Health. 2007;16(2):191–7.
27.
Homburg R. Pregnancy complications in PCOS. Best Practice & Research Clinical Endocrinology & Metabolism. 2006;20(2):281–92.
28.
Taylor AE, McCourt B, Martin KA, Anderson EJ, Adams JM, Schoenfeld D, et al. Determinants of Abnormal Gonadotropin Secretion in Clinically Defined Women with Polycystic Ovary Syndrome1. The Journal of Clinical Endocrinology & Metabolism. 1997;82(7):2248–56.
29.
Cheung AP, Lu JK, Chang RJ. Pulsatile gonadotrophin secretion in women with polycystic ovary syndrome after gonadotrophin-releasing hormone agonist treatment. Human Reproduction. 1997;12(6):1156–64.
30.
Memi G. Effect of mild exercise on chronic stress responses and role of hormones in this effect. In: Institute of Health Sciences, Department of Physiology, Master Thesis. 2015.
31.
DeUgarte CM, Bartolucci AA, Azziz R. Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. Fertility and Sterility. 2005;83(5):1454–60.
32.
Bremer AA. Polycystic Ovary Syndrome in the Pediatric Population. Metabolic Syndrome and Related Disorders. 2010;8(5):375–94.
33.
Mitwally MF, Casper RF. Aromatase inhibitors for the treatment of infertility. Expert Opinion on Investigational Drugs. 2003;12(3):353–71.
34.
Baysal B. Polikistik over sendromu ve hirsutizm. In: İÜ Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Etkinlikleri Sempozyum Dizisi. 2008. p. 99–107.
35.
Lecke SB, Morsch DM, Spritzer PM. Association between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome. Genetics and Molecular Research. 12(4):4292–6.
36.
Sheehan MT. Polycystic Ovarian Syndrome: Diagnosis and Management. Clinical Medicine & Research. 2004;2(1):13–27.
37.
Dokras A. Cardiovascular disease risk in women with PCOS. Steroids. 2013;78(8):773–6.
38.
Tura A, Göbl C, Pacini G. Effects of antidiabetic agents on pancreatic beta-cell function in gestational diabetes: is there enough evidence? Expert Opinion on Drug Metabolism & Toxicology. 2016;12(2):129–33.
39.
Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. The Lancet. 2006;368(9548):1696–705.
40.
Kolterman OG, Buse JB, Fineman MS, Gaines E, Heintz S, Bicsak TA, et al. Synthetic Exendin-4 (Exenatide) Significantly Reduces Postprandial and Fasting Plasma Glucose in Subjects with Type 2 Diabetes. The Journal of Clinical Endocrinology & Metabolism. 2003;88(7):3082–9.
41.
Nielsen LL, Young AA, Parkes DG. Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes. Regulatory Peptides. 2004;117(2):77–88.
42.
Artunc-Ulkumen B, Pala HG, Pala EE, Yavasoglu A, Yigitturk G, Erbas O. Exenatide improves ovarian and endometrial injury and preserves ovarian reserve in streptozocin induced diabetic rats. Gynecological Endocrinology. 2015;31(3):196–201.
43.
Bienertová-Vašků J, Zlámal F, Nečesánek I, Konečný D, Vasku A. Calculating Stress: From Entropy to a Thermodynamic Concept of Health and Disease. PLOS ONE. 11(1):e0146667.
44.
Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP. Stress and the female reproductive system. Journal of Reproductive Immunology. 2004;62(1–2):61–8.
45.
Chrousos GP, Torpy DJ, Gold PW. Interactions between the Hypothalamic-Pituitary-Adrenal Axis and the Female Reproductive System: Clinical Implications. Annals of Internal Medicine. 1998;129(3):229–40.

Citation

Article metrics

Google scholar: See link

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.