Introduction/Aims: Microvascular and macrovascular complications lead to recurrent hospital admissions, hospitalizations, disability, and death in the course of type 2 diabetes mellitus (T2DM). Triglyceride to HDL cholesterol ratio (THR) is associated with insulin resistance. We aimed to find out whether there is a relationship between THR and diabetic complications in patients with T2DM. Methods: Patients with T2DM were enrolled in the study. The study population was divided into two groups according to the presence or absence of diabetic complications. Characteristics and laboratory data of the patients with (group A) and without (group B) diabetic complications were compared. Results: Median THR values of the groups A and B were 3.86 (0.33-53.38) and 2.86 (0.63-17.88), respectively (p = 0.006). THR level was significantly and positively correlated with glycated hemoglobin (HbA1c) (r = 0.12, p = 0.04) and fasting glucose levels (r = 0.14, p = 0.02). Conclusion: We suggest that THR should be monitored in patients with type 2 diabetes mellitus in order to detect diabetic microvascular complications earlier. Increased THR levels should prompt further investigation of diabetic complications in this population.
References
1.
Atak BM, Duman TT, Aktas G, et al. Platelet Distribution Width is Associated with Type 2 Diabetes Mellitus and Diabetic Nephropathy and Neuropathy. National Journal of Health Sciences. 2018;3(3):95–8.
2.
Kurtkulagi O, Bilgin S, Kahveci GB, Atak Tel BM, Kosekli MA. Could triglyceride to high density lipoprotein-cholesterol ratio predict hepatosteatosis. Experimental Biomedical Research. 2021;4(3):224–9.
3.
Woo MH, Lee KO, Chung D, Choi JW, Kim SH, Oh SH. Triglyceride/HDL-Cholesterol Ratio as an Index of Intracranial Atherosclerosis in Nonstroke Individuals. Frontiers in Neurology. 11.
4.
Engin M, Güvenç O. Investigation of the Predictive Values of Triglyceride/HDL Cholesterol Ratio and Whole Blood Viscosity with Regard to Severe Peripheral or Carotid Artery Disease in Patients Scheduled for Coronary Bypass. The Heart Surgery Forum. 23(3):E310–4.
5.
Olabode OP, Akinlade OM, Babatunde AS, Abdulazeez MI, Biliaminu SA, Oyabambi AO, et al. Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease. Archives of Physiology and Biochemistry. 2020;126(2):166–71.
6.
Xia W, Yao X, Chen Y, Lin J, Vielhauer V, Hu H. Elevated TG/HDL-C and non-HDL-C/HDL-C ratios predict mortality in peritoneal dialysis patients. BMC Nephrology. 2020;21(1).
7.
Anderson JLC, Bakker SJL, Tietge UJF. The triglyceride to HDL-cholesterol ratio and chronic graft failure in renal transplantation. Journal of Clinical Lipidology. 2021;15(2):301–10.
8.
Anderson JLC, Bakker SJL, Tietge UJF. Triglyceride/HDL cholesterol ratio and premature all-cause mortality in renal transplant recipients. Nephrology Dialysis Transplantation. 2021;36(5):936–8.
9.
Tekce H, Tekce B, Aktas G, Alcelik A, Sengul E. Serum Omentin-1 Levels in Diabetic and Nondiabetic Patients with Chronic Kidney Disease. Experimental and Clinical Endocrinology & Diabetes. 122(08):451–6.
10.
Tekce BK, Tekce H, Aktas G, Sit M. Evaluation of the Urinary Kidney Injury Molecule-1 Levels in Patients With Diabetic Nephropathy. Clinical and Investigative Medicine. 2014;37(6):E377–83.
11.
Kocak MZ, Aktas G, Atak BM, Duman TT, Yis OM, Erkus E, et al. Is Neuregulin‐4 a predictive marker of microvascular complications in type 2 diabetes mellitus? European Journal of Clinical Investigation. 2020;50(3).
12.
Aktas G, Kocak MZ, Bilgin S, Atak BM, Duman TT, Kurtkulagi O. Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. The Aging Male. 2020;23(5):1098–102.
13.
Kocak MZ, Aktas G, Duman TT, Atak BM, Savli H. Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy? Revista da Associação Médica Brasileira. 65(9):1155–60.
14.
Deshpande AD, Harris-Hayes M, Schootman M. Epidemiology of Diabetes and Diabetes-Related Complications. Physical Therapy. 2008;88(11):1254–64.
15.
Kocak MZ, Aktas G, Duman TT, Atak BM, Kurtkulagi O, Tekce H, et al. Monocyte lymphocyte ratio As a predictor of Diabetic Kidney Injury in type 2 Diabetes mellitus; The MADKID Study. Journal of Diabetes & Metabolic Disorders. 2020;19(2):997–1002.
16.
He S, Wang S, Chen X, Jiang L, Peng Y, Li L, et al. Higher ratio of triglyceride to high-density lipoprotein cholesterol may predispose to diabetes mellitus: 15-year prospective study in a general population. Metabolism. 2012;61(1):30–6.
17.
Kim-Dorner SJ, Deuster PA, Zeno SA, Remaley AT, Poth M. Should triglycerides and the triglycerides to high-density lipoprotein cholesterol ratio be used as surrogates for insulin resistance? Metabolism. 2010;59(2):299–304.
18.
McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G. Use of Metabolic Markers To Identify Overweight Individuals Who Are Insulin Resistant. Annals of Internal Medicine. 2003;139(10):802–9.
19.
Ginsberg HN, Bonds DE, Lovato LC, Crouse JR, Elam MB, Linz PE, et al. Evolution of the Lipid Trial Protocol of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial. The American Journal of Cardiology. 2007;99(12):S56–67.
20.
Chahil TJ, Ginsberg HN. Diabetic Dyslipidemia. Endocrinology and Metabolism Clinics of North America. 2006;35(3):491–510.
21.
Almdal T, Scharling H, Jensen JS, Vestergaard H. The Independent Effect of Type 2 Diabetes Mellitus on Ischemic Heart Disease, Stroke, and Death. Archives of Internal Medicine. 2004;164(13):1422.
22.
Chawla R, Chawla A, Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum? Indian Journal of Endocrinology and Metabolism. 2016;20(4):546.
23.
Fuller J, Stevens L, Wang SL. Risk factors for cardiovascular mortality and morbidity: The WHO multinational study of vascular disease in diabetes. Diabetologia. 2001;44(S2):S54–64.
24.
Kalofoutis C, Piperi C, Kalofoutis A. Type II diabetes mellitus and cardiovascular risk factors: current therapeutic approaches. Exp Clin Cardiol. 2007;12(17).
25.
Hayfron-Benjamin C, van den Born BJ, Maitland - van der Zee AH, Amoah AGB, Meeks KAC, Klipstein-Grobusch K, et al. Microvascular and macrovascular complications in type 2 diabetes Ghanaian residents in Ghana and Europe: The RODAM study. Journal of Diabetes and its Complications. 2019;33(8):572–8.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
