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Triglyceride to high density lipoprotein cholesterol ratio is elevated in patients with complicated type 2 diabetes mellitus

By
Satilmis Bilgin ,
Satilmis Bilgin
Gulali Aktas ,
Gulali Aktas
Tel Atak ,
Tel Atak
Ozge Kurtkulagi ,
Ozge Kurtkulagi
Gizem Kahveci ,
Gizem Kahveci
Tuba Duman ,
Tuba Duman
Havva Akin ,
Havva Akin
Buse Balci ,
Buse Balci
Asli Erturk
Asli Erturk

Abstract

Microvascular and macrovascular complications lead to recurrent hospital admissions, hospitalizations, disability, and death in the course of type 2 diabetes mellitus (T2DM). Triglyceride to HDL cholesterol ratio (THR) is associated with insulin resistance. We aimed to find out whether there is a relationship between THR and diabetic complications in patients with T2DM. Patients with T2DM were enrolled in the study. The study population was divided into two groups according to the presence or absence of diabetic complications. Characteristics and laboratory data of the patients with (group A) and without (group B) diabetic complications were compared. Median THR values of the groups A and B were 3.86 (0.33-53.38) and 2.86 (0.63-17.88), respectively (p = 0.006). THR level was significantly and positively correlated with glycated hemoglobin (HbA1c) (r = 0.12, p = 0.04) and fasting glucose levels (r = 0.14, p = 0.02). We suggest that THR should be monitored in patients with type 2 diabetes mellitus in order to detect diabetic microvascular complications earlier. Increased THR levels should prompt further investigation of diabetic complications in this population.

References

1.
Atak BM, Duman TT, Aktas G, et al. Platelet Distribution Width is Associated with Type 2 Diabetes Mellitus and Diabetic Nephropathy and Neuropathy. National Journal of Health Sciences. 2018;3(3):95–8.
2.
Kurtkulagi O, Bilgin S, Kahveci GB, Atak Tel BM, Kosekli MA. Could triglyceride to high density lipoprotein-cholesterol ratio predict hepatosteatosis. Experimental Biomedical Research. 2021;4(3):224–9.
3.
Woo MH, Lee KO, Chung D, Choi JW, Kim SH, Oh SH. Triglyceride/HDL-Cholesterol Ratio as an Index of Intracranial Atherosclerosis in Nonstroke Individuals. Frontiers in Neurology. 11.
4.
Engin M, Güvenç O. Investigation of the Predictive Values of Triglyceride/HDL Cholesterol Ratio and Whole Blood Viscosity with Regard to Severe Peripheral or Carotid Artery Disease in Patients Scheduled for Coronary Bypass. The Heart Surgery Forum. 23(3):E310–4.
5.
Olabode OP, Akinlade OM, Babatunde AS, Abdulazeez MI, Biliaminu SA, Oyabambi AO, et al. Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease. Archives of Physiology and Biochemistry. 2020;126(2):166–71.

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