Aims. The aim of the study was to evaluate the association of mortality in acute pancreatitis with clinical and simple laboratory data received on the day of admission. Patients and methods. In our retrospective study, the clinical and laboratory parameters of 99 patients with moderate and severe acute pancreatitis were analyzed. All patients were divided into two groups: deceased and survivors. Results. We did not find a significant difference in age and gender distribution between the comparison groups. However, a significant predominance of alcoholic etiology of acute pancreatitis, early hospitalization (up to 6 hours from the onset of the disease) of patients, and the number of necrotizing infected type in the deceased group were found. Concomitant pathology did not significantly differ in comparison groups. In patients from the deceased group, the total number of all complications was significantly higher than in the group of survivors-21 (100%) and 42 (53.8%) (p = 0.0001), respecting. Among the laboratory parameters determined on the day of admission, in the deceased group, there was a significant increase in stabs to 19.8 ± 9.8 and ESR, AST to 225.3 ± 47.5 U/L, urea to 11.2 ± 7.7 mmol/L, and creatinine to 173.6 ± 26.1 mmol/L. Conclusion. The alcoholic genesis of acute pancreatitis, necrotizing infected type of inflammation of the pancreas, presence of late complications, and comorbidities were significantly higher in the deceased group. The levels of stabs, ESR, AST, urea, and creatinine determined on the admission significantly dominated in the deceased group, which requires further study for the prediction of mortality of acute pancreatitis.
References
1.
Miller J, Wu Y, Safa R, Marusca G, Bhatti S, Ahluwalia G, et al. Derivation and validation of the ED-SAS score for very early prediction of mortality and morbidity with acute pancreatitis: a retrospective observational study. BMC Emergency Medicine. 2021;21(1).
2.
Kikuta K. Impaired glucose tolerance in acute pancreatitis. World Journal of Gastroenterology. 2015;21(24):7367.
3.
Vasudevan S, Goswami P, Sonika U, Thakur B, Sreenivas V, Saraya A. Comparison of Various Scoring Systems and Biochemical Markers in Predicting the Outcome in Acute Pancreatitis. Pancreas. 2018;47(1):65–71.
4.
Büchler MW, Gloor B, Müller CA, Friess H, Seiler CA, Uhl W. Acute Necrotizing Pancreatitis: Treatment Strategy According to the Status of Infection. Annals of Surgery. 2000;232(5):619–26.
5.
Pando E, Alberti P, Mata R, Gomez MJ, Vidal L, Cirera A, et al. Early Changes in Blood Urea Nitrogen (BUN) Can Predict Mortality in Acute Pancreatitis: Comparative Study between BISAP Score, APACHE‐II, and Other Laboratory Markers—A Prospective Observational Study. Canadian Journal of Gastroenterology and Hepatology. 2021;2021(1).
6.
Silva-Vaz P, Abrantes AM, Morgado-Nunes S, Castelo-Branco M, Gouveia A, Botelho MF, et al. Evaluation of Prognostic Factors of Severity in Acute Biliary Pancreatitis. International Journal of Molecular Sciences. 21(12):4300.
7.
Junare PR, Debnath P, Nair S, Chandnani S, Udgirkar S, Thange R, et al. Complete hemogram: simple and cost-effective in staging and predicting outcome in acute pancreatitis. Wiener klinische Wochenschrift. 2021;133(13–14):661–8.
8.
Khanna AK, Meher S, Prakash S, Tiwary SK, Singh U, Srivastava A, et al. Comparison of Ranson, Glasgow, MOSS, SIRS, BISAP, APACHE-II, CTSI Scores, IL-6, CRP, and Procalcitonin in Predicting Severity, Organ Failure, Pancreatic Necrosis, and Mortality in Acute Pancreatitis. HPB Surgery. 2013;2013:1–10.
9.
Jinno N, Hori Y, Naitoh I, Miyabe K, Yoshida M, Natsume M, et al. Predictive factors for the mortality of acute pancreatitis on admission. PLOS ONE. 14(8):e0221468.
10.
Jeon TJ, Park JY. Clinical significance of the neutrophil-lymphocyte ratio as an early predictive marker for adverse outcomes in patients with acute pancreatitis. World Journal of Gastroenterology. 2017;23(21):3883.
11.
Lin N, Li Y, X Y. Patient-and hospitalbased factors at admission associated with outcomes of patients hospitalized for acute pancreatitis: a retrospective cohort study. Int J Clin Exp Med. 2016;9(12):23551–9.
12.
Koutroumpakis E, Wu BU, Bakker OJ, Dudekula A, Singh VK, Besselink MG, et al. Admission Hematocrit and Rise in Blood Urea Nitrogen at 24 h Outperform other Laboratory Markers in Predicting Persistent Organ Failure and Pancreatic Necrosis in Acute Pancreatitis: A Post Hoc Analysis of Three Large Prospective Databases. American Journal of Gastroenterology. 2015;110(12):1707–16.
13.
Shi L, Zhang D, Zhang J. Albumin–bilirubin score is associated with in-hospital mortality in critically ill patients with acute pancreatitis. European Journal of Gastroenterology & Hepatology. 2020;32(8):963–70.
14.
Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102–11.
15.
Suppiah A, Malde D, Arab T, Hamed M, Allgar V, Smith AM, et al. The Prognostic Value of the Neutrophil–Lymphocyte Ratio (NLR) in Acute Pancreatitis: Identification of an Optimal NLR. Journal of Gastrointestinal Surgery. 2013;17(4):675–81.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
