This study was undertaken to determine the antidiabetic and antioxidant effects of oral administration of ethanolic extract of Moringa oleiferaflower on stretozotocin-induced diabetic rats at 100, 200, and 300 mg/kg b.w. Thirty (30) male experimental albino rats were grouped randomly into six groups: groups A, B, and F are the control, diabetic control and reference drug groups, while C-E received 100, 200, and 300mg/kg b.w of the extract, respectively. Blood samples and organs were collected to assay for blood glucose level and antioxidant enzymes. Levels of blood glucose, serum lipids and lipid peroxidation as well as aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine aminotransferase (ALT) activities were significantly reduced (p < 0.05) in STZ-induced diabetic rats orally administered ethanolic extract of M. oleifera flower. However, the body weight; catalase and superoxide dismutase activities were significantly increased (p < 0.05) when compared with the controls. M. oleifera flower ethanolic extract administered orally therefore exhibited improved lipid metabolism, glucose-lowering potential and is hence beneficial in preventing diabetic complications as a result of lipid peroxidation and oxidative systems in streptozotocin-induced diabetic rats. It could thus be employed therapeutically in managing diabetes mellitus.
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Frederick S. Owens, Oluwabunmi Dada, John W. Cyrus, Oreoluwa O. Adedoyin, Georges Adunlin
(2020)
The effects of Moringa oleifera on blood glucose levels: A scoping review of the literature
Complementary Therapies in Medicine, 50()
10.1016/j.ctim.2020.102362
Iqra Liaquat, Arif-ullah Khan, Salman Khan
(2021)
RETRACTED: Pharmacological evaluation of continentalic acid for antidiabetic potential
Biomedicine & Pharmacotherapy, 138()
10.1016/j.biopha.2021.111411
Appavoo Umamaheswari, Sakthivel Lakshmana Prabu, Ayarivan Puratchikody
(2019)
Phytopharmacological potential of the natural gift Moringa oleifera Lam and its therapeutic application: An overview
Asian Pacific Journal of Tropical Medicine, 12(11)
10.4103/1995-7645.271288
Rong Liu, Jing Liu, Qi Huang, Shao Liu, Yueping Jiang
(2022)
Moringa oleifera: a systematic review of its botany, traditional uses, phytochemistry, pharmacology and toxicity
Journal of Pharmacy and Pharmacology, 74(3)
10.1093/jpp/rgab131
Melva Louisa, Cyntia Gracesella Hutami Patintingan, Bantari W. K. Wardhani
(2022)
Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions
Frontiers in Pharmacology, 13()
10.3389/fphar.2022.792794
Arise Rotimi Olusanya, Bankole S. Ifeoluwa, Aboyewa Jumoke A., Bobbo Khadijat
(2018)
Diabetes Food Plan
, ()
10.5772/intechopen.71529
Krasimir O. Boyanov, Mariya A. Choneva, Ivica Dimov, Iliyan V. Dimitrov, Tatyana I. Vlaykova, Fanka D. Gerginska, Slavi D. Delchev, Petar I. Hrischev, Katerina N. Georgieva, Anelia V. Bivolarska
(2022)
Effect of oligosaccharides on the antioxidant, lipid and inflammatory profiles of rats with streptozotocin-induced diabetes mellitus
Zeitschrift für Naturforschung C, 77(9-10)
10.1515/znc-2021-0215
Badriyah Aljazzaf, Sassia Regeai, Sana Elghmasi, Nadia Alghazir, Amal Balgasim, Ismail M. Hdud Ismail, Areej A. Eskandrani, Ghalia Shamlan, Wafa S. Alansari, Ammar AL-Farga, Rabia Alghazeer, Esra Kupeli Akkol
(2023)
Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study
Oxidative Medicine and Cellular Longevity, 2023()
10.1155/2023/9136217
Muhammad Shabir Ahmed, Arif-ullah Khan, Lina Tariq Al Kury, Fawad Ali Shah
(2020)
Computational and Pharmacological Evaluation of Carveol for Antidiabetic Potential
Frontiers in Pharmacology, 11()
10.3389/fphar.2020.00919
Shihori Watanabe, Hiyori Okoshi, Shizuko Yamabe, Masako Shimada
(2021)
Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis
Molecules, 26(12)
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