Although we could not find the registered cases of leptospirosis co-occurring with lymphogranulomatosis, it is important to note that both diseases can affect the immune system. Therefore, the reported case is unique and will be interesting and useful for the physicians of various specialties. We report a case of icterohemorrhagic form of leptospirosis with a fatal outcome in a woman with postmortem diagnosis of Hodgkin's lymphoma. Based on the findings of the autopsy, histological and immunohistochemical studies, it was established that the deceased suffered from Hodgkin's lymphoma during her life, classical form, reticular subtype with depletion of lymphoid tissue and extranodal spread in the liver, ovaries, and epicardium. The combination of leptospirosis and lymphogranulomatosis was characterized by the complication of the diagnostic process, which should be taken into account by physicians of all specialties.
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