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Review article

Cord Blood Transplantation in Adult Patients With Hematological Malignancies

By
Goran Marjanović ,
Goran Marjanović
Milena Todorović-Bakrač ,
Milena Todorović-Bakrač
Tatjana Jevtović-Stoimenov
Tatjana Jevtović-Stoimenov

Abstract

The purpose of this review was to show the available clinical and biological advances of umbilical cord blood allogeneic stem cell transplantation in adult patients. In adults, umbilical cord blood transplantation, due to less pronounced graft versus host disease compared to conventional approaches may, be feasible in spite of slower engraftment. The authors discussed certain attempts for improvement of umbilical cord stem cells engraftment.   

References

1.
Brunstein GC, Barker JN, Weisdorf DJ, DeFor TE, Miller JS, BR B, et al. Umbilical cord blood transplan tation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematolo gic disease Blood 2007. 8(110):3064–70.
2.
Fernandez MN, Regidor C, R C. Unrelated umbilical cord blood transplants in adults: Early recovery of neutrophils by supportive co-transplantation of a low number of highly purified peripheral blood CD34+ cells from an HLA-haploidentical donor. Exp Hematol. 2003;31:535–44.
3.
Fernandez MN, Regidor C, R C. Cord blood transplants: early recovery of neutrophils from co-tran splanted sibling haploidentical progenitor cells and lack of engraftment of cultured cord blood cells, as ascerta ined by analysis of DNA polymorphisms. Bone Marrow Transplant. 2001;28:355–63.
4.
Cord blood transplants supported by co-infusion of mobilized he matopoietic stem cells from a third-party donor. Bone Marrow Transplant. 2009;43:365–73.
5.
Ballen KK, Spitzer TR, BY Y. Double unrela ted reduced-intensity umbilical cord blood transplan tation in adults. Biol Blood Marrow Transplant. 2007;13:82–9.

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