×
Home
Archive Submission Guidelines
News Contact
Review article

Cord Blood Transplantation in Adult Patients With Hematological Malignancies

By
Goran Marjanović ,
Goran Marjanović
Milena Todorović-Bakrač ,
Milena Todorović-Bakrač
Tatjana Jevtović-Stoimenov
Tatjana Jevtović-Stoimenov

Abstract

The purpose of this review was to show the available clinical and biological advances of umbilical cord blood allogeneic stem cell transplantation in adult patients. In adults, umbilical cord blood transplantation, due to less pronounced graft versus host disease compared to conventional approaches may, be feasible in spite of slower engraftment. The authors discussed certain attempts for improvement of umbilical cord stem cells engraftment.   

References

1.
Kurtzberg J, Laughlin M, Graham ML, Smith C, Olson JF, EC H, et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med. 1996;335:157 66.
2.
Gluckman E, Rocha V, Boyer-Chammard A, Locatelli F, Arcese W, R P, et al. Outcome of cord blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group N Engl J Med. 1997;6(337):373–81.
3.
Rubinstein P, Carrier C, Scaradavou A, Kurtzberg J, Adamson J, AR M, et al. Outcomes among 562 recipients of placental blood transplants from unrelated donors. N Engl J Med. 1998;22(339):1565–77.
4.
Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C, et al. Transplantation of unrelated donor um bilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood. 2002;5(100):1611–8.
5.
Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, Miller JS, Wagner JE. Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced - intensity conditioning. Blood. 2003;5(102):1915–9.

Citation

Article metrics

Google scholar: See link

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.