Vascularization, proliferative activity and the p53 status in glioblastomas
Glioblastomas (GBMs) are among the most vascularized human tumors and the presence of microvascular proliferation is one of the diagnostic hallmarks of these malignancies. The aim of the present study was to investigate the extent of vascularization and its relation to proliferative activity and the p53 status in GBMs. Tissue samples from 100 selec...
By Desanka Tasić, Irena Dimov, Miloš Kostov, Dragan Dimov
Angiogenesis in glioblastoma: Molecular and cellular mechanisms and clinical applications
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults and carries poor prognosis. Despite advances in therapy, no significant increase in survival has been achieved for GBM patients. These tumors inevitably recur in the majority of patients, and the therapeutic options for recurrent tumors are limited. GBMs are aggressive, f...
By Desanka Tasić, Irena Dimov, Miloš Kostov, Nataša Vidović, Dragan Dimov
Mature Intracranial Teratoma
SUMMARY Teratomas constitute a group of nongerminomatous germ cell tumors that are composed of an admixture of different tissue types representative of ectoderm, endoderm and mesoderm. Intracranial teratomas are rare, comprising approximately 0.5% of all intracranial tumors. They preferentially involve the midline structures, and occur primari...
By Irena Dimov, Desanka Tasić, Ivana Stojanović, Simonida Stojanović, Nebojša Stojanović, Ivan Stefanović, Dragan Dimov
New Insights Into Molecular Basis of Glioblastoma Multiforme and Associated Immunosuppression
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By Irena Dimov, Desanka Tasić, Ivan Stefanović, Dragan Dimov