Numerous clinical trials have proven the connection between two glandular organs, in this case, the breast and the thyroid gland. The occurrence of breast cancer (BC) is increased in patients with autoimmune thyroid disease (Hashimoto's thyroiditis and Graves' disease). Patients with Graves' disease have a significantly smaller number of described ...

By Tijana Veljković, Dragana Bubanja, Nataša Zdravković, Željko Todorović, Radiša Vojinović, Mladen Maksić

Anatomically insignificant stenosis of coronary arteries obtained on coronary angiography, in numerous cases can show hemodynamic significance and as such cause ischemic myocardial changes. The goal was to assess the diagnostic accuracy of myocardial perfusion scintigraphy (SPECT MPI) in the detection of hemodinamically significant coronary artery ...

By Miloš Stević, Marina Vlajković, Filip Veličković, Tamara Anđelković, Nina Topić

Analgesics are drugs used in the pain pharmacotherapy and are one of the most prescribed drugs in all countries. Modern pain pharmacotherapy involves the use of analgesic steps. The objective of this paper was to analyze the consumption of drugs used in the pain pharmacotherapy in the Republic of Serbia (RS), in the period from 2015 to 2018, and to...

By Dane Krtinić, Boris Milijašević, Aleksandra Dragić, Dragana Milijašević, Aleksandra Lučić-Prokin, Gordana Nedin-Ranković, Irena Conić, Mirjana Todorović-Mitić, Hristina Jovanović, Hristina Trajković, Vuk Pejčić

The internal carotid artery (ICA) is a paired artery that primarily supplies the anterior two-thirds of the brain, the pituitary gland, the eye structures, and some other cranial structures. The ICA variations or abnormalities have been more or less described; especially, bilateral ICA hypoplasia (ICAH) was a very rare description that inspired aut...

By Ljiljana Vasović, Ana Mrkaić, Miracle Wangsuwana, Dimitrije Đorđević, Milena Trandafilović

Epidermal growth factor receptor (EGFR) is one of the key tumor markers of non-small cell lung cancer (NSCLC) and a guideline for the choice of therapeutic procedures. The research aims to evaluate the methods used in the investigation of EGFR variants in NSCLC cell lines and combined research (NSCLC cell lines and patient samples) in the last deca...

By Jovana Todosijević-Jovanović, Jasmina Obradović

Microencapsulation technology can be used for the protection of Alpha-tocopherol from degradation in unfavorable environments and enhancement of bioavailability and shelf-life of vitamin E. The aim of this study was the synthesis and characterization of alginate microparticles for the oral delivery of a-tocopherol. Four different formulations of Al...

By Milja Živković, Ana Barjaktarević, Marina Tomović, Anđela Uštević

Chronic apical periodontitis represents dynamic continuation of the presence of endodontic infection in the root canal system of the tooth, when the innate and acquired immune responses are activated and various cells and inflammatory mediators are recruited, which cause the consequent destruction of periapical tissues and the development of periap...

By Jelena Popović, Tatjana Cvetković, Tanja Džopalić, Aleksandar Mitić, Marija Nikolić, Radomir Barac, Nenad Stošić, Antonije Stanković

Currently, there is no classification reflecting the severity of complicated intra-abdominal infections (cIAIs). Therefore, we aimed to create one and facilitate the prognostic assessment of cIAIs in clinical practice. This was a single-center study conducted at a University Hospital Stara Zagora including 140 patients with cIAIs. Retrospectively, ...

By Evgeni Dimitrov, Georgi Minkov, Emil Enchev, Yovcho Yovtchev

During the SARS-CoV-2 pandemic, there was a significant number of cases accompanied by thrombosis. The precise pathophysiological mechanism remains unclear. The importance of the fibrinolytic mechanism in maintaining physiological hemostasis led us to explore its potential contribution to COVID-19-induced thromboembolism. This study aimed to identi...

By Igor Spasić, Dejan Dobrijević, Biljana Vučković

Polypharmacy can increase the risk of side effects and cause adverse drug interactions with a significant impact on the course of the basic disease. The aim of the study was to determine the frequency of polypharmacy and examine its impact on the risk of drug-drug interactions in patients with rheumatoid arthritis (RA). The research was conducted i...

By Nikola Krstić, Nikola Stefanović, Milan Petronijević, Ivana Damnjanović