Acute intermittent porphyria is a rare metabolic disorder of the hem biosynthetic pathway that can cause severe neurological symptoms involving the central, autonomic and peripheral nervous system. Diagnosis may be delayed due to variable symptoms that can mimic other diseases. A 23-year-old woman with abdominal pain, constipation, progressive deve...

By Stefan Todorović, Gordana Đorđević, Andrija Rančić, Dejan Aleksić

The internal carotid artery (ICA) is a paired artery that primarily supplies the anterior two-thirds of the brain, the pituitary gland, the eye structures, and some other cranial structures. The ICA variations or abnormalities have been more or less described; especially, bilateral ICA hypoplasia (ICAH) was a very rare description that inspired aut...

By Ljiljana Vasović, Ana Mrkaić, Miracle Wangsuwana, Dimitrije Đorđević, Milena Trandafilović

The incidence of acute myocardial infarction (AMI) is declining in developed countries due to better prevention and more effective treatment of risk factors, however, the proportion of younger patients with AMI is increasing. The aim of the research was to compare patients under the age of 45 years with acute myocardial infarction at a ten-year int...

By Danijela Đorđević-Radojković, Miodrag Damjanović, Svetlana Apostolović, Jelena Milošević, Dragana Stanojević, Goran Koraćević, Ružica Janković-Tomašević, Tomislav Kostić, Sonja Dakić, Jelena Cvetković, Jovana Šarić

Currently, there is no classification reflecting the severity of complicated intra-abdominal infections (cIAIs). Therefore, we aimed to create one and facilitate the prognostic assessment of cIAIs in clinical practice. This was a single-center study conducted at a University Hospital Stara Zagora including 140 patients with cIAIs. Retrospectively, ...

By Evgeni Dimitrov, Georgi Minkov, Emil Enchev, Yovcho Yovtchev

Seminal fluid analysis (SFA) plays a crucial role in helping infertility clinics diagnose the underlying reason of male infertility. The aim of the study was to investigate seminal fluid patterns of male partners of an infertile couple with apparently fertile female partners. A cross-sectional study was conducted between January 2019 and December 2...

By Harith Mohamed Kamber, Kamal Al-Jawdah, Salam Madhi Shahid, Zaid Al-Atta

Systemic lupus erythematosus (SLE) represents a multisystemic disease characterized by antibody production, complement activation, and immune complexes deposition. Certain types of malignancies occur more often, and conversely, some of them occur less often in SLE patients. Mucosal melanoma of the anorectal region represents a rare form of melanoma...

By Aleksandar Popović, Ivan Petković, Andrija Rančić, Aleksandra Dimitrijević, Vesna Brzački, Stefan Stankov, Andrija Jović, Sonja Stojanović

Diabetes is one of the most common diseases among hospitalized patients due to COVID-19. Therefore, this study aimed to identify the clinical characteristics of diabetic and non-diabetic patients with COVID-19 that may lead to death. A multicenter cross-sectional study was conducted among patients admitted to hospitals due to COVID-19. The data, in...

By Mehrnaz Ahmadi, Javad Zarei, Ali Hadianfard, Touba Moghadam

Necrotizing soft tissue infections are actually the diseases with a severe outcome characterized by the progression of soft tissue inflammation with a catastrophic prognosis and the risk of major functional consequences. Only prompt diagnosis and prompt care, including prompt administration of appropriate antibiotic therapy and surgical treatment, ...

By Mladen Kasalović, Gojko Igrutinović, Zlatan Elek, Aleksandar Jakovljević, Nikola Miljković, Milica Milentijević

Acrania is a very rare lethal congenital malformation characterized by an absence of the cranial vault with developed cerebral hemispheres. It is sometimes confused with anencephaly in which both the forebrain and neurocranium are not developed. Although these two conditions principally differ in their morphology and pathogenesis, acrania may be a ...

By Vladimír Bartoš, Oľga Káčeríková

This present study focuses on the findings of clinical trials that have revealed unsatisfactory results and mortality escalation rates of patients suffering from serious traumatic brain injuries (TBI). The main objective of this research was to investigate whether hyperglycaemia is a significant indicator of mortality in patients with the diagnosis...

By Awatara Danta, Thirza Quila