This study examined the probable effects of graded doses of Cannabis sativa (C. sativa) extract on the gene expressions of monoamine oxidase B and serotonin receptor 2C (HTR2C) in an attempt to correlate the duration of use with neurodegeneration tendencies in chronic marijuana users. Male Wistar rats weighing between 90 g ± 100 g were treat...

By Oluwatosin Dosumu, Oluwafemi Owolabi, Regina Ugbaja, Akinola Popoola, Solomon Rotimi, Odunayo Taiwo, Oluwafemi Ojo

Traditional research means, such as in vitro and in vivo models, have consistently been used by scientists to test hypotheses in biochemistry. Computational (in silico) methods have been increasingly devised and applied to testing and hypothesis development in biochemistry over the last decade. The aim of in silico methods is to analyze the quantit...

By Aleksandar Velesinović, Goran Nikolić

Ballet is a professional activity that places risky physical and psycho-emotional demands on the human body. The goal of this study was to evaluate health-related problems among ballet dancers. Within the qualitative study, in-depth interviews were conducted with ballet dancers at the State Ballet of Georgia. Participants' mean age was 23.4 &plusmn...

By Tengiz Verulava, Ketevan Tvalavadze, Revaz Jorbenadze

The aim of the research was a histological study of the tissue structure of experimental animals with burns in dynamics using various topical agents after the injury. Experimental simulation of burn injuries was performed on 40 rats, which were divided into the main and control groups. Depending on the nature of care provided, the animals of the ma...

By Roman Chornopyshchuk, Vasyl Nagaichuk, Oleksandr Nazarchuk, Svetlana Sidorenko, Olena Urvan

Ertapenem, a member of the carbapenem group of antibiotics, is a broad-spectrum antibiotic that is effective against multidrug-resistant gram-positive and gram-negative infections. In patients with acute or chronic kidney damage, one of the most serious side effects of ertapenem is neurotoxicity. Various clinical conditions such as seizures, halluc...

By Alper Alp, Yalkin Dalda

Nowadays, the appropriate control of rheumatoid arthritis (RA) involves the absence of clinical disease activity, delaying joint destruction as long as possible and adequate quality of life of the affected. With currently available therapeutic modalities, this therapeutic goal can be achieved in a large number of patients. The aim of this research ...

By Sonja Stojanović, Bojana Stamenković, Jovan Nedović, Ivana Aleksić, Jovana Cvetković

Pulmonary arterial hypertension (PAH), which occurs in about 15% of patients with systemic sclerosis (SSc), is a progressive vasculopathy and despite modern therapeutic options is still one of the leading causes of death in these patients. We presented a patient diagnosed with the overlap syndrome (systemic sclerosis and rheumatoid arthritis) with ...

By Ivana Aleksić, Sandra Šarić, Bojan Ilić, Sonja Stojanović, Marina Deljanin-Ilić

Sigmoid sinus septic thrombosis is an infrequent complaint that may lead to extensive morbidity and mortality. We report a case with septic thrombosis of the sigmoid sinus caused by chronic mastoiditis and otitis media. A 29-year-old male presented with a 14-day history of tinnitus and true vertigo with a gradually developing swelling on the right ...

By Soheil Ebrahimpour, Mahmoud Sadeghi-Haddad-Zavareh, Zeinab Afshar, Arefeh Babazadeh

Considerable share of patients admitted to the intensive care unit, during the current Covid-19 pandemic, are obese. Obesity is associated with chronic low-grade inflammation, higher endothelial injury, higher levels of angiotensinogen II and increased expression of angiotensin-converting enzyme 2 receptors in the adipose tissue. These alterations ...

By Vesna Marjanović

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults and carries poor prognosis. Despite advances in therapy, no significant increase in survival has been achieved for GBM patients. These tumors inevitably recur in the majority of patients, and the therapeutic options for recurrent tumors are limited. GBMs are aggressive, f...

By Desanka Tasić, Irena Dimov, Miloš Kostov, Nataša Vidović, Dragan Dimov