Ketorolac is a potent non-steroidal anti-inflammatory drug (NSAID) that can inhibit cyclooxygenase activity and prostaglandin synthesis, thereby reducing pain and inflammation. The aim of this study was to investigate the hepatorenal toxicity of ketorolac administration in adult male rats. Twenty-four adult male Wistar rats were randomly assigned t...

By Fatemeh Rashidi, Amir Noyani, Salma Omidi, Touraj Assadi

Cystic changes of the spleen are one of the rare clinical entities in the pediatric population. The paper presents a partial splenectomy in children performed by open approach as a safe surgical treatment of giant epithelial splenic cysts. Two cases of giant epithelial cysts of the spleen in children are presented. Medical documents and data referr...

By Maja Zečević, Zoran Marjanović, Dragoljub Živanović, Goran Janković, Nikola Živković, Živojin Spasić, Strahinja Konstantinović

Artificial intelligence (AI) offers transformative potential in healthcare management by enhancing predictive analytics, optimizing resource allocation, and supporting clinical decision-making. This study aims to examine the applications of AI in Serbian healthcare institutions, focusing on improving operational efficiency and patient outcomes. The...

By Milić Kimi, Šćepan Sinanović, Tatjana Kilibarda, Saša Bubanj, Novica Bojanić, Tanja Prodović

Splenic abscess is a very rare extra-intestinal complication of Salmonella infection in the post-antibiotic era with the incidence between 0.14% and 2%. It usually follows bacteremia due to varied etiologies such as trauma, infective endocarditis, intravenous drug abuse, immunodeficiency status (AIDS, diabetes mellitus). An 82-year-old woman presen...

By Milan Pantelić, Tamara Vučinić, Milica Stanucević, Miloš Dujović, Maša Pantelić

Many markers are used to evaluate the prognosis in patients with acute myocardial infarction (AMI). Researches are focused on available markers with high sensitivity and specificity. The aim of our study was to evaluate the prognostic value of N-terminal pro brain natriuretic peptide (NT-proBNP) and its superiority compared with other prognostic ma...

By Rada Vučić, Vladimir Ignjatović, Olivera Andrejić, Katarina Čupić, Miodrag Srećković, Filipović Vučković, Marija Sekulić, Milan Dobrić, Jelena Rakočević

Glioblastomas (GBMs) are among the most vascularized human tumors and the presence of microvascular proliferation is one of the diagnostic hallmarks of these malignancies. The aim of the present study was to investigate the extent of vascularization and its relation to proliferative activity and the p53 status in GBMs. Tissue samples from 100 selec...

By Desanka Tasić, Irena Dimov, Miloš Kostov, Dragan Dimov

When making complete dentures, both functional and aesthetic criteria need to be met so that the patient can accept the prosthetic restoration more easily and be satisfied with it. The aim of the research was to determine smile parameters as anthropological criteria for the selection of teeth when making complete dentures. The study included 91 den...

By Milena Kostić, Marko Igic, Marija Đorđević, Ermin Đerlek, Ana Pejcic, Nikola Gligorijević, Ivana Stankovic, Nadica S. Đorđević, Marija Andjelkovic Apostolovic

Multiple sclerosis (MS) is a chronic, autoimmune demyelinating disease of the central nervous system. The association of vitamin D deficiency, sun exposure, and higher incidence of multiple sclerosis has been known for long, and a number of studies have confirmed anti-inflammatory and neuroprotective properties of vitamin D. Vitamin D receptor (VDR...

By Lazar Bajić, Dejan Savic, Nikola Krstić, Ana Andrejević, Andrija Rančić, Miljana Mladenović, Tatjana Jevtovic Stoimenov

The emergence of the COVID-19 pandemic has underscored the critical importance of accurate and reliable methods for the early detection and management of cases. Traditional approaches to COVID-19 diagnosis often rely on binary classification methods, which may limit their accuracy and robustness. In this study, we propose a novel approach that leve...

By Affaf Khaouane, Latifa KHAOUANE, Samira FERHAT, Salah HANINI

Shock is a life-threatening condition that occurs due to a mismatch in the supply and consumption of oxygen, which leads to cell and tissue hypoxia, resulting in cell death and dysfunction of vital organs. The effects of shock are reversible in the early stages, but delay in diagnosis and initiation of treatment can lead to irreversible changes. Th...

By Uroš Ristić, Radmilo Janković, Marija Stošić, Milan Manić, Jelena Živadinović, Dalibor Stojanović, Biljana Stošić