Spastic cerebral palsy (CP) is the most common type of CP. Up to 80% of all individuals with cerebral palsy suffer from some degree of spasticity. Spasticity adversely affects muscles and joints of the extremities, causing abnormal movements, and it is especially harmful in growing children. Several methods have been developed and used to assess sp...

By Lidija Dimitrijević, Hristina Čolović, Marija Spalević, Anita Stanković, Dragan Zlatanović, Bratislav Cvetković

Quality of life (QOL) in families can be affected when a child has cerebral palsy (CP). The aim of this research was to determine the effect of a child’s disability on the mother’s quality of life by comparing mothers of children with CP and mothers of normal children. Two sample groups were chosen from a total of 42 mothers to answer a...

By Samira Borzoo, Mansoureh Nickbakht, Mehrdad Jalalian

The main issue in patients with pulmonary tuberculosis (PTB) represents the impossibility of the host immune response to express bactericidal function and the sterilization of lesions depends exclusively on the specific antimicrobial chemotherapy. In order to investigate the value of acute-phase inflammatory response markers in patients with newly ...

By Milan Radović, Tatjana Pejčić, Ivana Stanković, Lidija Ristić, Milan Rančić, Zorica Ćirić

The study of features of pharmacodynamics of a new analgesic is an important and urgent task of modern pharmacology. These data allow us to clarify the nosology for application of an analgesic and to create a theoretical background to optimize its use. An effect mediated by the transient receptor potential cation channel, subfamily V, member 1 (TRP...

By Oleh Yadlovskyi, Tatiana Bukhtiarova, Lyudmila Bobkova, Irina Tatianshenko, Igor Monchak, Andrew Khayrulin

Emergency hormonal contraception is used to prevent unintended pregnancy postcoitally. The mechanism of action of the most frequently used hormonal preparations for emergency contraception, levonorgestrel (LNG) and ulipristal acetate (UPA), is still not fully known, but clinical trials indicate that they act by inhibiting or delaying ovulation. LNG...

By Jelena Milosavljević, Katarina Ilić, Dušanka Krajnović

In search for new and promising coumarin compounds as HIV-1 integrase inhibitors, chemoinformatic methods like quantitative structure-activity relationships (QSAR) modeling and molecular docking have an important role since they can predict desired activity and propose molecule binding to enzyme. The aim of this study was building of QSAR models fo...

By Jovana Veselinović, Aleksandar Veselinović, Andrey Toropov, Alla Toropova, Ivana Damnjanović, Goran Nikolić

Osteoporosis is a chronic disease with increasing incidence that predominantly occurs in female population. There are evidences that bisphosphonates, selective estrogen receptor modulators, denosumab, teriparatide and strontium renalate, prevent vertebral fractures while alendronate, risedronate, zoledronic acid, denosumab and strontium renalate pr...

By Ivana Tadić, Ljiljana Tasić, Nada Vujašinović Stupar, Katarina Ilić, Dejan Stevanović

Symptoms of bladder dysfunction are significant public health problem due to their prevalence, morbidity and treatment costs. Most stem from bladder control problem which is governed by the brain, yet we know little about CNS and bladder. Advances in brain imaging technology have brought new insight in how brain works in different bladder diseases ...

By Staša Tadić

The aim of this study was to investigate the exogenous agmatine influence on nitrosative and oxidative stress parameters in acute phase of multiple sclerosis (MS) experimental model, experimental autoimmune encephalomyelitis (EAE). EAE was induced by subcutaneous injection of myelin basic protein (50 μg per animal). Sprague-Dawley rats were divi...

By Ivana Stojanović, Srđan Ljubisavljević, Ivana Stevanović, Slavica Stojnev, Radmila Pavlović, Dušan Sokolović, Aleksandar Petrović, Dušica Pavlović, Tatjana Cvetković

Reproductive health implies that people are able to have a responsible, satisfying and safe sex life and that they have the capability to reproduce and the freedom to decide about it. It is directly conditioned by social, cultural and behavior factors. One in every five people in the world is an adolescent, and 85% of them live in developing countr...

By Olivera Radulović, Slađana Babić, Milena Veljković, Ana Stefanović, Čedomir Šagrić, Katarina Bulatović