The study of features of pharmacodynamics of a new analgesic is an important and urgent task of modern pharmacology. These data allow us to clarify the nosology for application of an analgesic and to create a theoretical background to optimize its use. An effect mediated by the transient receptor potential cation channel, subfamily V, member 1 (TRP...

By Oleh Yadlovskyi, Tatiana Bukhtiarova, Lyudmila Bobkova, Irina Tatianshenko, Igor Monchak, Andrew Khayrulin

Emergency hormonal contraception is used to prevent unintended pregnancy postcoitally. The mechanism of action of the most frequently used hormonal preparations for emergency contraception, levonorgestrel (LNG) and ulipristal acetate (UPA), is still not fully known, but clinical trials indicate that they act by inhibiting or delaying ovulation. LNG...

By Jelena Milosavljević, Katarina Ilić, Dušanka Krajnović

Osteoporosis is a chronic disease with increasing incidence that predominantly occurs in female population. There are evidences that bisphosphonates, selective estrogen receptor modulators, denosumab, teriparatide and strontium renalate, prevent vertebral fractures while alendronate, risedronate, zoledronic acid, denosumab and strontium renalate pr...

By Ivana Tadić, Ljiljana Tasić, Nada Vujašinović Stupar, Katarina Ilić, Dejan Stevanović

Symptoms of bladder dysfunction are significant public health problem due to their prevalence, morbidity and treatment costs. Most stem from bladder control problem which is governed by the brain, yet we know little about CNS and bladder. Advances in brain imaging technology have brought new insight in how brain works in different bladder diseases ...

By Staša Tadić

Teratomas constitute a group of nongerminomatous germ cell tumors that are composed of an admixture of different tissue types representative of ectoderm, endoderm and mesoderm. Intracranial teratomas are rare, comprising approximately 0.5% of all intracranial tumors. They preferentially involve the midline structures, and occur primarily in childre...

By Irena Dimov, Desanka Tasić, Ivana Stojanović, Simonida Stojanović, Nebojša Stojanović, Ivan Stefanović, Dragan Dimov

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults and carries the poorest prognosis despite aggressive multimodal therapy. The majority of GBMs develop de novo (primary) with a short clinical history, while secondary GBMs develop through progression from preexisting lowergrade precursor gliomas and show distin...

By Irena Dimov, Desanka Tasić, Ivan Stefanović, Dragan Dimov

Cervical cancer is the third most common malignant neoplasm in women. It is also the fourth cause of death in women amongst malignant neoplasms in the Toplica District. The aim of the paper was to show the most important epidemiological characteristics of cervical cancer and to analyze its incidence and mortality trends during the period 1999-2012....

By Mirko Ilić, Biljana Kocić, Nataša Rančić

Chronic kidney disease (CKD) is an important worldwide public health problem and stroke represents a continuously evolving medical and social problem. Renal dysfunction carries a substantial risk for cardiovascular morbidity and mortality, the risk increases with a decline in kidney function. In the last 15 years the link between CKD and cerebrovas...

By Radovan Hojs, Tanja Hojs Fabjan

The degree of patient cooperation plays a key role in the success of antihypertensive drug therapy. Non-adherence is the major health and economic problem in the treatment of arterial hypertension (HTA). The aim of the study was to evaluate the degree of adherence in hypertensive patients and to study risk factors affecting adherence and the effect...

By Jelena Lalić, Radmila Veličković Radovanović, Branka Mitić, Valentina Nikolić, Ana Spasić, Goran Koraćević

Nutrition plays a very important role in every physical fitness program. Despite many advances in nutritional knowledge and dietary practices, sports nutrition-associated issues are still a challenge. The aim of this study was to determine and compare nutritional knowledge and behavior among the youth practicing sports situated in two different Eur...

By Gabriele Trabucco, Maja Nikoić, Bojana Vuković Mirković