The aim of this study is to present the importance of pharmacologic therapy in an early prevention of bleeding and rebleeding from the oesophageal varices in patients with portal hypertension. Three hundred and fifteen patients with liver cirrhosis have been evaluated and diagnosed in the University Clinic of Gastroenterohepatology. In the evaluati...

By Nenad Joksimović, Vladimir Andreevski, Magdalena Genadieva, Meri Trajkovska

Numerous comorbidities are frequently associated with asthma and may influence the clinical expression and severity of asthma. The aim of our study was to determine the presence and prevalence of other diseases in children with asthma, both of allergic and non-allergic origin. The study included 974 non - hospital patients, of whom 669 had asthma, ...

By Sanja Dimitrijević, Snežana Živanović, Ljiljana Šaranac

Obsessive-compulsive disorder (OCD) is defined by the presence of either obsession or compulsion that is severe enough to be time consuming or to cause marked distress or significant impairment. At some point during the course of the disorder, the person recognizes that the obsessions and compulsions are excessive or unreasonable. Twenty-one patien...

By Lydia Sushevska, Nichola Olumchev, Mirjana Saveska

Perforation of peptic ulcer (PPU) is the most frequent complication of peptic ulcer disease. PPU is a serious complication which demands urgent diagnostic procedures, reanimation and surgical intervention. The aim of this study was to establish the frequency of PPU, diagnostic and therapy procedures, time and kind of surgical methods, as well as mo...

By Ivana Đorđević, Aleksandar Zlatić, Irena Janković

Abdominal aortic aneurysm (AAA) is a complex disease defined as a pathologic dilatation of the infrarenal aorta that is often accompanied by significant superimposed atherosclerosis, inflammation and thrombosis. AAAs are a significant cause of morbidity and mortality in the United States and worldwide. While some patients may present with lower bac...

By Philip Tsao, Ivana Burazor

Malignant melanoma presents unusual predilection for metastasizing in small intestine, becoming one of the most common malignancies that metastasize in small intestine. Intestinal metastases can be identified at the moment of primary disease or later, as a first sign of recurrence. We report a case of malignant melanoma metastatic to the GI tract. ...

By Gjorgji Jota, Zoran Karadzov, Milčo Panovski, Nenad Joksimović, Andrijan Kartalov, Radomir Gelevski, Vladimir Joksimović

For the purpose of economic evaluation in the health economics, several analytical techniques that are designed for comparing two or more health interventions in terms of costs and effects are used. Cost-benefit analysis provides the opportunity of comparing values of alternative health interventions that have very different health benefits, which ...

By Aleksandar Višnjić, Vladica Veličković, Nataša Šelmić Milosavljević

Between 1996 and 2004, a total of 708 patients were enrolled in the AML ´96 and 2002 studies of the East German Study Group. Of those, 138 patients (19.5%) had unfavourable cytogenetics defined as complex karyotype, del (5q)/-5, del (7q)/-7, abn (3q26) and abn (11q23). Seventy-seven (56%) patients achieved CR1 after induction chemotherap...

By Nadežda Basara, Antje Schulze, Herbert Sayer

Scanty information is available regarding the clinical characteristics, quality of life (QoL) profile and manometric findings in unselected newly diagnosed cases of achalasia. Fifty-six consecutive cases of newly diagnosed achalasia have been characterized regarding the symptoms when a standardized protocol was applied, to which was added a more de...

By Srđan Kostić, Magnus Ruth, Ann Kjellin, Lars Lundell, Erik Svartholm, Mats Andersson, Hans Lönroth

High performance liquid chromatography with diode array detection (HPLC -DAD) was used to study the autoxidation of gallic acid in alkaline aqueous solutions and the influence of Mg(II) ion on this process. At pH 10, one main autoxidation product was determined, and based on the data obtained in this study its structure was proposed to some kind of...

By Goran Nikolić, Aleksandar Veselinović, Žarko Mitić, Slavoljub Živanović