,
To evaluate the influence of exercise training on inflammatory markers and exercise tolerance in coronary artery disease (CAD) patients. A total of 54 subjects were enrolled in the present study, including 34 CAD patients (CAD group: 59.2 ± 8.2 years) and 20 healthy controls (C group: 54.2 ± 8.0 years). C reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC), and placental growth factor (PIGF) were determined, and an exercise test was performed in both groups at baseline and once again in CAD group after the supervised 3 weeks of aerobic exercise training. At baseline, CRP, ESR and PIGF were significantly higher in the CAD group compared to the C group (p = 0.038, p = 0.019 and p = 0.002), while exercise capacity was significantly higher in the C group (p < 0.01). After 3 weeks of exercise training, CRP, ESR, WBC count and PIGF significantly decreased (p = 0.048, p < 0.001, p = 0.002 and p < 0.001 respectively), while exercise capacity significantly increased (p < 0.001) in the CAD group. In the CAD group, CRP decrease significantly correlated with WBC and PIGF decrease (r = 0.816, p = 0.002 and r = 0.988, p < 0.001), as well as with exercise capacity increase (r = 0.834, p < 0.001). Also, WBC decrease significantly correlated both with PIGF decrease (r = 0.768, p < 0.001) and exercise capacity increase (r = 0.548, p = 0.012), while PIGF decrease significantly correlated with exercise capacity increase (r = 0.548, p = 0.013). Residential exercise training in CAD patients reduces inflammation, expressed through a significant decrease in CRP, ESR, WBC count and PIGF levels. Those positive changes in inflammatory markers are associated with significant improvement in exercise capacity.
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
2
Milovan Stojanović, Marija Stanković, Marina Deljanin-Ilić, Aleksa Vuković, Jelena Igrutinović-Novković, Igor Igić, Stevan Ilić, Dejan Petrović
(2024)
Effects of cardiovascular rehabilitation on exercise tolerance and quality of life in elderly with coronary artery disease
AFMN Biomedicine, 41(2)
10.5937/afmnai41-48746
Milovan Stojanović, Ilić Deljanin, Stevan Ilić
(2022)
The effects of cardiovascular rehabilitation in patients with reduced, mildly reduced, and preserved ejection fraction: Do they benefit equally?
Srce i krvni sudovi, 41(4)
10.5937/siks2202039SThe statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.