Anoctamin-1 (ANO1, TMEM16A), a transmembrane protein belonging to the ANO family, plays a role in the formation of calcium-activated chloride channels (CaCCs). It is involved in the regulation of physiological processes, including muscle contraction, gastrointestinal motility, secretion, and electrical excitability. Also, recent data suggest that A...

By Vladimir Petrovic, Aleksandra Veličkov, Marko Jović, Julija Radenković, Braca Kundalić, Dušan Miljković, Vukota Radovanović, Goran Radenković

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with chronic inflammation recognized as a critical factor in its pathogenesis. This review focuses on the roles of pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-17A (IL-17A), alongside the anti-inflammatory cytokine interleukin-10 (IL-10), in CR...

By Lana Sarajlić, Edin Hodžić, Alma Mekić Abazović, Samir Muhović, Amina Mehić, Emsad Halilović, Salem Bajramagić, Adnan Kulo, Ramajana Šukić-Karalić

Malocclusions are common oral health issues that require precise assessment of severity and the need for orthodontic treatment. The Index of Orthodontic Treatment Need (IOTN) is a reliable tool for objectively evaluating the necessity of orthodontic therapy. This study aimed to determine the need for orthodontic treatment among children and adolesc...

By Andjelka Cvijić, Iva Jakovljević, Aleksandra Arnaut, Roberta Marković, Tatjana Čutović

Inflammatory bowel disease (IBD) is a significant cause of morbidity and disability in pediatric patients, characterized by chronic intestinal inflammation. Biologic therapies, such as adalimumab and infliximab, are widely used for induction and maintenance of remission. Therapeutic drug monitoring (TDM) enables individualized treatment by optimizi...

By Jasmina Katanić, Dejan Dobrijević, Mirjana Stojšić

Nizon-Isidor syndrome (NIZIDS) is a rare genetic disorder associated with mutations in the MED12L gene and is usually characterized by a distinctive facial appearance, neurodevelopmental delay, autism spectrum disorders (ASD), and chronic gastrointestinal symptoms (GIS). In this case report, we emphasize the importance of early evaluation of geneti...

By Mehmet Semih Demirtaş, Yakup Köylü

Older edentulous adults often rely on mucosa-supported complete dentures (CDs) due to limitations that preclude implant therapy. Although an adequate retention of maxillary CD is essential for functional efficiency, compression of the palatal mucosa during impression making may compromise palatal mucosal microcirculation during denture wear. T...

By Petar Tekić, Stefan Vulović, Marija Milić, Marko Igić, Milena Kostić, Aleksandra Popovac, Ivica Stančić, Aleksandra Milić Lemić

Loeffler's endocarditis (LE) is a rare form of inflammatory cardiomyopathy. The condition arises from diffuse eosinophilic infiltration of the endomyocardium, followed by eosinophil degranulation and progressive tissue fibrosis. The aim of this case report is to present a rare form of restrictive cardiomyopathy, LE, in a young female patient, and t...

By Milica Kotur, Nikola Pantić, Lenka Grujičić, Isidora Grozdić-Milojević, Dragana Šobić-Šaranović, Vera Artiko, Strahinja Odalović

Diabetes mellitus is one of the most common chronic diseases in childhood. The aim of this study was to evaluate the oral health of children with type 1 diabetes in relation to the level of glycemic control. 87 children aged 10 to 15 participated in the study, divided into two groups according to the value of glycosylated hemoglobin (HbA1c): 34 chi...

By Mirjana Djuričković, Aleksa Djuričković

Aluminium is a metal that disrupts the pro-oxidant and antioxidant balance in tissues, leading to biochemical dysfunction. The present study evaluated the protective effect of rutin on aluminium chloride (AlCl3)-induced hepatorenal toxicity in Wistar rats. Twenty male Wistar rats were divided into four groups: Group 1-control, Group 2 received AlCl...

By Olu Israel Oyewole, Ayoola Mary Bukoye

COVID-19 infection may exacerbate glycemia and lead to metabolic problems in people with diabetes. Emerging data suggest that diabetes may also develop during coronavirus infection in individuals with no prior history of the disease. This study aimed to analyze the prevalence of new-onset hyperglycemia and diabetes mellitus (nDM) in COVID-19 patien...

By Samar Maher Yassin, Zaid Al-Attar