Malocclusions are common oral health issues that require precise assessment of severity and the need for orthodontic treatment. The Index of Orthodontic Treatment Need (IOTN) is a reliable tool for objectively evaluating the necessity of orthodontic therapy. This study aimed to determine the need for orthodontic treatment among children and adolesc...

By Andjelka Cvijić, Iva Jakovljević, Aleksandra Arnaut, Roberta Marković, Tatjana Čutović

Aronia melanocarpa (chokeberry, aronia) is rich in polyphenols and associated with vascular protective effects; however, comparative data on different aronia-derived products and their mechanisms remain limited. This study aimed to compare the vasorelaxant effects of aronia berry extract (AE), aronia waste extract (AWE), and aronia juice (AJ), and ...

By Milica Milutinović, Suzana Branković, Nada Ćujić Nikolić, Katarina Šavikin, Milica Randjelović, Bojana Miladinović, Dušanka Kitić

Inflammatory bowel disease (IBD) is a significant cause of morbidity and disability in pediatric patients, characterized by chronic intestinal inflammation. Biologic therapies, such as adalimumab and infliximab, are widely used for induction and maintenance of remission. Therapeutic drug monitoring (TDM) enables individualized treatment by optimizi...

By Jasmina Katanić, Dejan Dobrijević, Mirjana Stojšić

Nizon-Isidor syndrome (NIZIDS) is a rare genetic disorder associated with mutations in the MED12L gene and is usually characterized by a distinctive facial appearance, neurodevelopmental delay, autism spectrum disorders (ASD), and chronic gastrointestinal symptoms (GIS). In this case report, we emphasize the importance of early evaluation of geneti...

By Mehmet Semih Demirtaş, Yakup Köylü

SGLT-2 inhibitors have been associated with increases in hemoglobin and hematocrit levels; however, the independence of this effect from confounding factors remains unclear in real-world settings. This study aimed to determine whether hemoglobin and hematocrit levels differed between patients with type 2 diabetes mellitus using SGLT-2 inhibitors an...

By Ali Turunç, Melike Saday Bozkurt

The transition process to adulthood is a challenging but crucial period for the future well-being of patients with chronic diseases. The objective of this study was to evaluate whether specific clinical variables and disease activity status are associated with improved transition readiness among patients with juvenile idiopathic arthritis (JIA) and...

By Dragana Lazarević, Hristina Stamenković, Stefan Đorđević, Dušica Novaković, Maja Zečević, Gordana Sušić

Preterm prelabor rupture of membranes (PPROM) is a major cause of neonatal morbidity and mortality. Placental Protein 14 (PP14), a glycodelin glycoprotein, has emerged as a potential biomarker for the diagnosis of PPROM. The study aimed to evaluate the diagnostic accuracy of PP14 in detecting fetal membrane rupture. This case-control study was cond...

By Alaa Ali Rahi, Miami Abdul Hassan Ali

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects the reproductive, metabolic, and psychological health of women of reproductive age. Conventional therapies for PCOS primarily focus on symptom management; however, their associated side effects have led many women to explore complementary approaches. This review aimed to ...

By Gala Žarković, Vladimir Jakovljević, Saša Raičević, Angela Ćorić, Rosa Čukić Ćorović, Nikola Jović, Jovana Joksimović Jović

Halogenated boroxine is an important enzyme inhibitor with potential applications in cancer therapy. This study aimed to evaluate its effects on hematological parameters in rats in vivo and creatine kinase activity in vitro. Halogenated boroxine, administered either intraperitoneally (IP) or orally, induced route-dependent changes in hematological ...

By Safija Herenda, Elma Hasković, Muhamed Fočak, Alem Bekan, Sabina Prevljak, Nenad Vanis, Mirza Halimić, Alen Džubur, Edhem Hasković

Artificial intelligence (AI)-assisted digital mental health interventions are being increasingly discussed as a potential strategy for improving access to psychological support among adolescents with anxiety symptoms and anxiety disorders. Their possible advantages include flexible availability, reduced barriers to help-seeking, psychoeducation, sy...

By Aleksandra Stojanović, Miodrag Stanković, Aleksandra Ristić