Oxidative stress and resulting lipid peroxidation are involved in numerous pathological conditions. For this reason, the role of antioxidants attracts attention and the radical-scavenging capacity of many natural and synthetic supplements and drugs has been extensively evaluated. In the present study, seven N,N'-disubstituted benzimidazole-2-thione...

By Jelena Lazarević, Jelena Zvezdanović, Neda Anastassova, Anelia Mavrova, Denitsa Yancheva, Andrija Šmelcerović

Toxoplasmosis modifies various hormones and cytokines in the infected hosts which may result in several disorders. This study was conducted to assess testosterone, DHEA, and prolactin concentration levels among Toxoplasma gondii infected and uninfected infertile couples. Blood samples were collected and sera were separated. The sera were analyzed f...

By Masomeh Bayani, Narges Kalantari, Sedigheh Esmailzadeh, Salman Ghaffari, Soleiman Mahjoub, Faezeh Ghofrani, Taraneh Ghaffari

Biologics (biopharmaceuticals) present new promising therapies for many diseases such as cancers, chronical inflammatory diseases and today's biggest challenge - COVID-19. Today, most biologics have been synthetized using modern methods of biotechnology, in particular DNA recombinant technology. Current pharmaceutical forms of protein/peptide bioph...

By Sanja Stanković, Marija Tasić-Kostov

Pseudothrombocytopenia induced by ethylenediaminetetraacetic acid is a rare phenomenon caused by autoantibodies against platelet membrane with overall prevalence of 0.1% in the general population. This phenomenon is an in vitro artifact and with different anticoagulant used, the patient had the physiological platelet count. This case is a report of...

By Dejan Dobrijević, Nataša Kaćanski-Rađenović, Jovanka Kolarović

The aim of the study was to evaluate the association of mortality in acute pancreatitis with clinical and simple laboratory data received on the day of admission. In our retrospective study, the clinical and laboratory parameters of 99 patients with moderate and severe acute pancreatitis were analyzed. All patients were divided into two groups: dec...

By Tetiana Formanchuk, Volodymyr Shaprinskiy, Andrii Formanchuk

Lung cancer is the leading cause of mortality from cancer across the world. In this study, the use of serum nucleolin (NCL) and nucleophosmin (NPM1) levels as a marker in the diagnosis, prognosis and treatment response evaluation in lung cancer was investigated. NCL and NPM1 levels of serum samples taken before chemotherapy and after 3-4 courses of...

By Gül Akın, Onur Esbah, Recep Eröz

This study aimed to predict the molecular targets of cipargamin in humans and estimate the structural dynamics and binding affinity of their interactions compared to that of Plasmodium falciparum P-type ATPase 4 (PfATP4). In silico methods were used in this study which include target prediction, structure modeling and dynamics, and molecular dockin...

By Toluwase Fatoki, Oladoja Awofisayo, Bolanle Faleye

Cognitive disorders and chronic diseases such as diabetes are common problems of aging. The aim of this study was to determine and compare the cognitive status of diabetic and non-diabetic elderly in the past ten years in primary health care in Iran. This cross-sectional study was performed on people aged 60 years and older in Kerman, Iran in 2020....

By Vahidreza Borhaninejad, Maryam Saber

The key links in the etiology and pathogenesis of periodontal tissue diseases are the quantitative and qualitative changes in the composition of the microflora of the oral cavity, with the simultaneous deterioration of oral hygiene, and reduction of local and general immunity, which occurs more often in the presence of somatic diseases. The aim of ...

By Iryna Lisetska, Mikola Rozhko

Non-steroidal anti-inflammatory drugs (NSAIDs) are ranked first among the world's effective anti-inflammatory and analgesic drugs with anticipated side effects. That is why the prevention of development of adverse reactions associated with NSAIDs, in particular, of those related to their ulcerogenicity, remains a serious global problem. Aims. To ch...

By Fedir Hladkykh