Protein-protein interaction networks and protein-ligand docking: Contemporary insights and future perspectives
Traditional research means, such as in vitro and in vivo models, have consistently been used by scientists to test hypotheses in biochemistry. Computational (in silico) methods have been increasingly devised and applied to testing and hypothesis development in biochemistry over the last decade. The aim of in silico methods is to analyze the quantit...
By Aleksandar Velesinović, Goran Nikolić
Health problems of professional ballet dancers
Ballet is a professional activity that places risky physical and psycho-emotional demands on the human body. The goal of this study was to evaluate health-related problems among ballet dancers. Within the qualitative study, in-depth interviews were conducted with ballet dancers at the State Ballet of Georgia. Participants' mean age was 23.4 ±...
By Tengiz Verulava, Ketevan Tvalavadze, Revaz Jorbenadze
Common mistakes in the choice of topical agents for emergency care of burns: Experimental study
The aim of the research was a histological study of the tissue structure of experimental animals with burns in dynamics using various topical agents after the injury. Experimental simulation of burn injuries was performed on 40 rats, which were divided into the main and control groups. Depending on the nature of care provided, the animals of the ma...
By Roman Chornopyshchuk, Vasyl Nagaichuk, Oleksandr Nazarchuk, Svetlana Sidorenko, Olena Urvan
Ertapenem neurotoxicity in patients with kidney damage: A case report
Ertapenem, a member of the carbapenem group of antibiotics, is a broad-spectrum antibiotic that is effective against multidrug-resistant gram-positive and gram-negative infections. In patients with acute or chronic kidney damage, one of the most serious side effects of ertapenem is neurotoxicity. Various clinical conditions such as seizures, halluc...
By Alper Alp, Yalkin Dalda
Effectiveness of Tocilizumab after switching from intravenous to subcutaneous formulation in patients with rheumatoid arthritis: A single-centre experience
Nowadays, the appropriate control of rheumatoid arthritis (RA) involves the absence of clinical disease activity, delaying joint destruction as long as possible and adequate quality of life of the affected. With currently available therapeutic modalities, this therapeutic goal can be achieved in a large number of patients. The aim of this research ...
By Sonja Stojanović, Bojana Stamenković, Jovan Nedović, Ivana Aleksić, Jovana Cvetković
Chronic chloroquine and ethanol administration causes detrimental renal morphological changes in rats fed low protein
The aim of the study was to investigate the microscopic renal changes resulting from the concurrent administration of chloroquine and ethanol, with inadequate dietary protein using rats. Sixty-four rats were randomly distributed into eight groups of eight rats each: control groups on normal protein (NPC) or low protein diet (LPC); chloroquine treat...
By Abdurrahman Abdulkadir, Ejikeme Mbajiorgu
The burden of tuberculosis as a permanent medical and legal challenge for mankind through centuries
Tuberculosis (TB) is a contagious disease, and throughout human history, it has been permanently opening numerous medical and legal questions, for which the answers are implied by the current social circumstances. In ancient times, insufficient knowledge of the etiopathogenesis of TB resulted in discrimination and isolation of patients. In the Midd...
By Milan Radović, Aleksandar Đorđević, Borislav Božanić
Systemic sclerosis and pulmonary arterial hypertension: A case report
Pulmonary arterial hypertension (PAH), which occurs in about 15% of patients with systemic sclerosis (SSc), is a progressive vasculopathy and despite modern therapeutic options is still one of the leading causes of death in these patients. We presented a patient diagnosed with the overlap syndrome (systemic sclerosis and rheumatoid arthritis) with ...
By Ivana Aleksić, Sandra Šarić, Bojan Ilić, Sonja Stojanović, Marina Deljanin-Ilić
Predictors of sexual dysfunction in HIV-infected women
Sexual dysfunction is more common among the people with human immunodeficiency virus (HIV) infection than in those without it. The sexual dysfunction in HIV-infected people is associated with adverse outcomes such as reduced quality of life, unprotected sexual activities, and reduced adherence to highly active antiretroviral therapy. Therefore, the...
By Zeinab Moshfeghy, Fatemeh Dadgar, Roksana Janghorban, Tahereh Poordast
Shocked to happy: Experiences of Iranian diabetics in reaction to the bad news of the diagnosis
Diagnosis of a chronic disease like type 2 diabetes mellitus (T2DM) is frequently shocking for patients, which influences their lives. Getting aware of bad news such as obtaining a chronic illness diagnosis is a sensitive issue in patients' lives. Conversely, reactions to the reception of a diagnosis of diabetes are often varied for a few reasons. ...
By Areshtanab Namdar, Moonaghi Karimi, Maryam Vahidi, Leila Jouybari, Zeydi Emami, Hossein Ranjbar