This study examined the probable effects of graded doses of Cannabis sativa (C. sativa) extract on the gene expressions of monoamine oxidase B and serotonin receptor 2C (HTR2C) in an attempt to correlate the duration of use with neurodegeneration tendencies in chronic marijuana users. Male Wistar rats weighing between 90 g ± 100 g were treat...

By Oluwatosin Dosumu, Oluwafemi Owolabi, Regina Ugbaja, Akinola Popoola, Solomon Rotimi, Odunayo Taiwo, Oluwafemi Ojo

One of the primary goals in endodontics is efficient cleaning and shaping of the root canal while maintaining its original configuration. Numerous studies highlight the advantage of using nickel-titanium instruments and the most important is their high flexibility and the ability to penetrate the curved canals. The aim of this study was to analyze ...

By Nenad Stošić, Jelena Popović, Marija Anđelković-Apostolović, Aleksandar Mitić, Marija Nikolić, Radomir Barac

Traditional research means, such as in vitro and in vivo models, have consistently been used by scientists to test hypotheses in biochemistry. Computational (in silico) methods have been increasingly devised and applied to testing and hypothesis development in biochemistry over the last decade. The aim of in silico methods is to analyze the quantit...

By Aleksandar Velesinović, Goran Nikolić

The aim of the research was a histological study of the tissue structure of experimental animals with burns in dynamics using various topical agents after the injury. Experimental simulation of burn injuries was performed on 40 rats, which were divided into the main and control groups. Depending on the nature of care provided, the animals of the ma...

By Roman Chornopyshchuk, Vasyl Nagaichuk, Oleksandr Nazarchuk, Svetlana Sidorenko, Olena Urvan

Ertapenem, a member of the carbapenem group of antibiotics, is a broad-spectrum antibiotic that is effective against multidrug-resistant gram-positive and gram-negative infections. In patients with acute or chronic kidney damage, one of the most serious side effects of ertapenem is neurotoxicity. Various clinical conditions such as seizures, halluc...

By Alper Alp, Yalkin Dalda

Pelvis is a strong bony-ligamentous structure containing many organs, vessels and nerves. Three forces or a combination of those forces produce pelvic fractures. The main causes of pelvic fractures are traffic accidents and falls from height. Biomechanically pelvic ring can be stable or unstable. Biomechanically unstable pelvic ring after the injur...

By Saša Milenković, Milan Mitković

Peripheral T/NK–cell lymphomas (PTCL) are rare, bizarre, and extremely diverse cancers. The disease is prone to relapse with a high level of chemorefractoriness leading to a poor outcome. Almost 70% of patients will experience relapse, with a median 5–year overall survival (OS) in approximately 30%. Upfront management of PTCL has been e...

By Ivan Petković, Aleksandar Popović, Miljana Džunić, Ivica Pejčić

Hyperuricemia and chronic deposition of monosodium urate crystals are the main cause of the gout. Urate lowering therapy (ULT) is the mainstay of chronic gout treatment. In this study, we evaluated demographic features and disease properties of the patients that would relate with the success of ULT. Sixty-six gout patients on pharmacologic ULT were...

By Nimet Kalkan, Mehmet Tezcan

Normal development is one of the reliable criteria for the assessment of children's health status. Perinatal events affect the future development of children. Nevertheless, there are different views on the impact of events in the perinatal period on child development. The aim of this study was to determine the relationship between perinatal period ...

By Masoumeh Kaviani, Zhaleh Ranjbaran, Roksana Janghorban

Considerable share of patients admitted to the intensive care unit, during the current Covid-19 pandemic, are obese. Obesity is associated with chronic low-grade inflammation, higher endothelial injury, higher levels of angiotensinogen II and increased expression of angiotensin-converting enzyme 2 receptors in the adipose tissue. These alterations ...

By Vesna Marjanović