Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with chronic inflammation recognized as a critical factor in its pathogenesis. This review focuses on the roles of pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-17A (IL-17A), alongside the anti-inflammatory cytokine interleukin-10 (IL-10), in CR...

By Lana Sarajlić, Edin Hodžić, Alma Mekić Abazović, Samir Muhović, Amina Mehić, Emsad Halilović, Salem Bajramagić, Adnan Kulo, Ramajana Šukić-Karalić

Anoctamin-1 (ANO1, TMEM16A), a transmembrane protein belonging to the ANO family, plays a role in the formation of calcium-activated chloride channels (CaCCs). It is involved in the regulation of physiological processes, including muscle contraction, gastrointestinal motility, secretion, and electrical excitability. Also, recent data suggest that A...

By Vladimir Petrovic, Aleksandra Veličkov, Marko Jović, Julija Radenković, Braca Kundalić, Dušan Miljković, Vukota Radovanović, Goran Radenković

Diabetes mellitus is one of the most common chronic diseases in childhood. The aim of this study was to evaluate the oral health of children with type 1 diabetes in relation to the level of glycemic control. 87 children aged 10 to 15 participated in the study, divided into two groups according to the value of glycosylated hemoglobin (HbA1c): 34 chi...

By Mirjana Djuričković, Aleksa Djuričković

Aluminium is a metal that disrupts the pro-oxidant and antioxidant balance in tissues, leading to biochemical dysfunction. The present study evaluated the protective effect of rutin on aluminium chloride (AlCl3)-induced hepatorenal toxicity in Wistar rats. Twenty male Wistar rats were divided into four groups: Group 1-control, Group 2 received AlCl...

By Olu Israel Oyewole, Ayoola Mary Bukoye

COVID-19 infection may exacerbate glycemia and lead to metabolic problems in people with diabetes. Emerging data suggest that diabetes may also develop during coronavirus infection in individuals with no prior history of the disease. This study aimed to analyze the prevalence of new-onset hyperglycemia and diabetes mellitus (nDM) in COVID-19 patien...

By Samar Maher Yassin, Zaid Al-Attar

Pre-eclampsia is a multiorgan disease process characterized by hypertension and proteinuria after 20 weeks of gestation. The aim of the study was to assess the serum level of anti-Müllerian hormone (AMH) in pregnant women as a predictor for pre-eclampsia. A case control study was carried out in Baghdad Teaching Hospital from 2020 to 2021. A sa...

By Wasan Wajdi, Ishraq Mohammed Kadhim, Raghad Nabeel Al-Khayyat

Zinc is a trace element involved in insulin metabolism, including its production, storage, and release. Selenium is regarded as a vital micronutrient for humans. It participates in insulin signaling and control. Zinc and selenium may be possibly linked to insulin resistance; however, these relationships have not been well investigated. Therefore, w...

By Fahad Hammadi, Hamdan Bader, Al-Mayah Sharhan

Splenic abscess is a very rare extra-intestinal complication of Salmonella infection in the post-antibiotic era with the incidence between 0.14% and 2%. It usually follows bacteremia due to varied etiologies such as trauma, infective endocarditis, intravenous drug abuse, immunodeficiency status (AIDS, diabetes mellitus). An 82-year-old woman presen...

By Milan Pantelić, Tamara Vučinić, Milica Stanucević, Miloš Dujović, Maša Pantelić

Ketorolac is a potent non-steroidal anti-inflammatory drug (NSAID) that can inhibit cyclooxygenase activity and prostaglandin synthesis, thereby reducing pain and inflammation. The aim of this study was to investigate the hepatorenal toxicity of ketorolac administration in adult male rats. Twenty-four adult male Wistar rats were randomly assigned t...

By Fatemeh Rashidi, Amir Noyani, Salma Omidi, Touraj Assadi

Immune thrombocytopenic purpura (ITP) is a common cause of thrombocytopenia in pediatric patients, often requiring differentiation from hypoproductive thrombocytopenia. This study assesses the diagnostic accuracy of immature platelet fraction (IPF) parameters in distinguishing ITP from hypoproductive thrombocytopenia. A cross-sectional study was co...

By Shahla Ansari, Zahra Soheilirad