Hyperuricemia and chronic deposition of monosodium urate crystals are the main cause of the gout. Urate lowering therapy (ULT) is the mainstay of chronic gout treatment. In this study, we evaluated demographic features and disease properties of the patients that would relate with the success of ULT. Sixty-six gout patients on pharmacologic ULT were...

By Nimet Kalkan, Mehmet Tezcan

Among many factors influencing human beauty, the correct position of the upper front teeth, including central incisors, is undoubtedly of particular importance. When determining the intermaxillary relationship, an important phase is determination of the medial line of a person’s face or places of contact of the upper central incisors. The aim...

By Marko Igić, Milena Kostić, Nebojša Krunić, Ana Pejčić, Stefan Dačić, Nenad Stošić

Rhabdoid morphology is a rare differentiation pattern that can occur in any type of renal cell carcinoma. In approximately 5% of renal tumors, a variable percent of rhabdoid cells can be seen. Even though these cells resemble rhabdomyoblasts, they are large, with large eccentric nuclei and prominent nucleoli; they have different immunophenotype and...

By Milena Potić-Floranović, Ana Ristić-Petrović, Filip Veličković, Milan Potić, Tanja Džopalić, Ljubinka Janković-Veličković

Liposomes have been used as universal carriers for decades, encapsulating many compounds with different cosmetic effects in order to achieve the quality, safety and efficacy of functional cosmetic products. In the present study, the efficacy of the application of the commercial liposome gel (SOPHY Anti-Aging Liposomal Intimate Gel), containing L-ar...

By Ivana Nešić, Vesna Savić, Ana Kolarević

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults and carries poor prognosis. Despite advances in therapy, no significant increase in survival has been achieved for GBM patients. These tumors inevitably recur in the majority of patients, and the therapeutic options for recurrent tumors are limited. GBMs are aggressive, f...

By Desanka Tasić, Irena Dimov, Miloš Kostov, Nataša Vidović, Dragan Dimov

Genetic counselling is a complex process that helps people to understand and adopt medical, psychological and genetic aspects of the disease and enable them to make an appropriate decision. In this framework, we revisited all the existing models for decision-making and suggested their use in the process of genetic counselling, which may lead to mor...

By Marija Lević, Dušanka Krajnović, Valentina Marinković

Comorbidity Index (CCI) is a simple method for the demonstration of comorbidity burden. This study aimed to assess the validity and reliability of the CCI among Iranian community-dwelling older adults. This cross-sectional study was carried out on a sample of 600 community-dwelling older adults aged 60 years and over in Tehran, Iran, 2017. A multis...

By Raziye Hosseini, Yadollah Momtaz, Farahnaz Shahboulaghi, Masoome Aghamaleki

The purpose of the study was to investigate the effects of Exendin-4 on polycystic ovary syndrome (PCOS) in rats in chronic mild stress medium. For establishing the PCOS model, dehydroepiandrosterone (DHEA) (6mg/100g) in 0.2ml sesame oil was injected subcutaneously to 21-day old rats (n = 67). In addition, 0.2ml sesame oil was injected subcutaneous...

By Burcu Köksal, Sedat Yildiz, Tugba Ozgöcer, Azibe Yildiz, Nigar Vardi, Özlem Barutcu

Achilles tendon injuries most commonly occur in athletes, but also in the middle-aged population practicing recreational sports. The aetiology of injury and disease of the Achilles tendon has not been completely clarified. While acute injury can be attributed to trauma, research showed that a chronic degenerative process is present in most ruptures...

By Mihajlo Mitrović, Dražen Jelača, Ivana Mitrović

The review highlights the characteristics of adipose tissue as a metabolically active organ, reveals endocrinous functions of adipose tissue and the role of adipose tissue in immune system’s functioning. The role of obesity in the development of insulin resistance (IR) and diabetes mellitus type 2 and the effect of dyslipidemia on the develop...

By Oksana Tkachenko, Iryna Polishchuk, Nadiya Gorchakova, Hanna Zaychenko