Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with chronic inflammation recognized as a critical factor in its pathogenesis. This review focuses on the roles of pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-17A (IL-17A), alongside the anti-inflammatory cytokine interleukin-10 (IL-10), in CR...

By Lana Sarajlić, Edin Hodžić, Alma Mekić Abazović, Samir Muhović, Amina Mehić, Emsad Halilović, Salem Bajramagić, Adnan Kulo, Ramajana Šukić-Karalić

Anoctamin-1 (ANO1, TMEM16A), a transmembrane protein belonging to the ANO family, plays a role in the formation of calcium-activated chloride channels (CaCCs). It is involved in the regulation of physiological processes, including muscle contraction, gastrointestinal motility, secretion, and electrical excitability. Also, recent data suggest that A...

By Vladimir Petrovic, Aleksandra Veličkov, Marko Jović, Julija Radenković, Braca Kundalić, Dušan Miljković, Vukota Radovanović, Goran Radenković

The quality and number of remaining teeth, bone quality, feasibility of dental implant treatment, condition of the supporting tissues, and the patient's financial condition must be considered when planning prosthetic rehabilitation for partially edentulous patients. Herein, we report the prosthetic rehabilitation of a 59-year-old man with a unilate...

By Srdjan D. Poštić

Computer vision technology is increasingly used in modern surgery to enhance patient safety through real-time automatic detection of critical operative events. However, challenges related to video quality, lighting conditions, and camera angles can affect system performance.This study aimed to develop and evaluate an artificial intelligence-based s...

By Marko Kimi Milić, Tanja Prodović, Šćepan Sinanović, Saša Bubanj

Pre-eclampsia is a multiorgan disease process characterized by hypertension and proteinuria after 20 weeks of gestation. The aim of the study was to assess the serum level of anti-Müllerian hormone (AMH) in pregnant women as a predictor for pre-eclampsia. A case control study was carried out in Baghdad Teaching Hospital from 2020 to 2021. A sa...

By Wasan Wajdi, Ishraq Mohammed Kadhim, Raghad Nabeel Al-Khayyat

Zinc is a trace element involved in insulin metabolism, including its production, storage, and release. Selenium is regarded as a vital micronutrient for humans. It participates in insulin signaling and control. Zinc and selenium may be possibly linked to insulin resistance; however, these relationships have not been well investigated. Therefore, w...

By Fahad Hammadi, Hamdan Bader, Al-Mayah Sharhan

Rheumatoid arthritis (RA) is a systemic autoimmune disease that can cause destructive joint disease and progressive disability. The diagnosis of RA is based on laboratory and clinical evidence, which includes the analysis of inflammatory markers, hematological, and biochemical parameters. Fifty patients diagnosed with RA without methotrexate (MTX) ...

By Maja Mitrašinović-Brulić, Ema Maslo, Muhamed Fočak, Damir Suljević

Splenic abscess is a very rare extra-intestinal complication of Salmonella infection in the post-antibiotic era with the incidence between 0.14% and 2%. It usually follows bacteremia due to varied etiologies such as trauma, infective endocarditis, intravenous drug abuse, immunodeficiency status (AIDS, diabetes mellitus). An 82-year-old woman presen...

By Milan Pantelić, Tamara Vučinić, Milica Stanucević, Miloš Dujović, Maša Pantelić

Ketorolac is a potent non-steroidal anti-inflammatory drug (NSAID) that can inhibit cyclooxygenase activity and prostaglandin synthesis, thereby reducing pain and inflammation. The aim of this study was to investigate the hepatorenal toxicity of ketorolac administration in adult male rats. Twenty-four adult male Wistar rats were randomly assigned t...

By Fatemeh Rashidi, Amir Noyani, Salma Omidi, Touraj Assadi

Immune thrombocytopenic purpura (ITP) is a common cause of thrombocytopenia in pediatric patients, often requiring differentiation from hypoproductive thrombocytopenia. This study assesses the diagnostic accuracy of immature platelet fraction (IPF) parameters in distinguishing ITP from hypoproductive thrombocytopenia. A cross-sectional study was co...

By Shahla Ansari, Zahra Soheilirad