Malocclusions are common oral health issues that require precise assessment of severity and the need for orthodontic treatment. The Index of Orthodontic Treatment Need (IOTN) is a reliable tool for objectively evaluating the necessity of orthodontic therapy. This study aimed to determine the need for orthodontic treatment among children and adolesc...

By Andjelka Cvijić, Iva Jakovljević, Aleksandra Arnaut, Roberta Marković, Tatjana Čutović

Inflammatory bowel disease (IBD) is a significant cause of morbidity and disability in pediatric patients, characterized by chronic intestinal inflammation. Biologic therapies, such as adalimumab and infliximab, are widely used for induction and maintenance of remission. Therapeutic drug monitoring (TDM) enables individualized treatment by optimizi...

By Jasmina Katanić, Dejan Dobrijević, Mirjana Stojšić

The transition process to adulthood is a challenging but crucial period for the future well-being of patients with chronic diseases. The objective of this study was to evaluate whether specific clinical variables and disease activity status are associated with improved transition readiness among patients with juvenile idiopathic arthritis (JIA) and...

By Dragana Lazarević, Hristina Stamenković, Stefan Đorđević, Dušica Novaković, Maja Zečević, Gordana Sušić

Preterm prelabor rupture of membranes (PPROM) is a major cause of neonatal morbidity and mortality. Placental Protein 14 (PP14), a glycodelin glycoprotein, has emerged as a potential biomarker for the diagnosis of PPROM. The study aimed to evaluate the diagnostic accuracy of PP14 in detecting fetal membrane rupture. This case-control study was cond...

By Alaa Ali Rahi, Miami Abdul Hassan Ali

Approximately 50% of embryo transfer cycles are performed as frozen embryo transfer (FET) cycles; however, research on the factors influencing pregnancy rates in these cycles is limited in northern Iran. The aim of this study was to identify the factors influencing the clinical pregnancy rate in hormone replacement therapy (HRT) FET cycles among in...

By Sepideh Peivandi, Samaneh Aghajanpour, Mohammad Khademloo, Keshvar Samadaee Gelehkolaee, Marzieh Zamaniyan

Multiple sclerosis (MS) is a chronic, autoimmune demyelinating disease of the central nervous system. The association of vitamin D deficiency, sun exposure, and higher incidence of multiple sclerosis has been known for long, and a number of studies have confirmed anti-inflammatory and neuroprotective properties of vitamin D. Vitamin D receptor (VDR...

By Lazar Bajić, Dejan Savic, Nikola Krstić, Ana Andrejević, Andrija Rančić, Miljana Mladenović, Tatjana Jevtovic Stoimenov

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in pediatric population and adolescents. Limited data is available on the characteristics of RMS in Iraqi pediatric patients. The aim of the study was to examine the clinical and histological aspects of RMS in Iraqi children, with a focus on their response to treatment, prognosis, and su...

By Abbas Olewi, Manaf Ahmed, Salih Mahdi, Zaid Al-Attar

Patients classified as belonging to simplified pulmonary embolism severity index (sPESI) class 0 are considered to have low-risk pulmonary embolism (PE). Yet, certain laboratory and echocardiographic parameters not accounted for in the sPESI score might suggest a likelihood of worse outcomes in PE cases. This study seeks to determine if the prognos...

By Aleksandra Kozić, Sonja Šalinger, Zorica Dimitrijević, Dragana Stanojević, Tomislav Kostić, Boris Džudović, Irena Mitevska, Jovan Matijašević, Aleksandar Nešković, Vladimir Miloradović, Tamara Kovačević-Preradović, Ana Kovačević-Kuzmanović, Slobodan Obradović

Artificial intelligence (AI) is increasingly recognized as a novel tool in enhancing psychotherapy, particularly for adolescents. The integration of AI-based platforms into mental health care promises improved accessibility, personalized interventions, and support for therapeutic processes. We aimed to evaluate the usability, safety, and preliminar...

By Miodrag Stanković, Aleksandra Stojanović

Behçet’s disease is a systemic, chronic, idiopathic inflammatory illness of unknown etiology with a recurrent course, manifested by a characteristic triad: recurrent aphthous stomatitis, ulcerative changes in the mucous membranes and skin of the genital organs, and inflammatory changes in the eyes. In addition, the musculoskeletal syst...

By Vita Ruzhanska, Iuliia Pashkova, Dmytro Grebeniuk, Andrii Sidorov, Svitozar Prevar, Oleksandr Smiiukha, Yuriy Hnatiyk, Arina Ivanitsa