Rutin (quercetin-3-O-rutinoside) is one of the most abundant bioflavonoids with various biological and pharmacological activities. Considering the ubiquitous presence of Mg(II) and Ca(II) ions in biological systems we decided to investigate their influence on the autoxidation of rutin in weakly alkaline aqueous solutions. Changes in UV-Vis spectra ...

By Slavoljub C. Živanović, Ružica S. Nikolić, Goran M. Nikolić

Combating Staphylococcus aureus (S. aureus) infections using antibacterial drugs is actually an ongoing effort to overcome resistance mechanism of this microorganism. In this paper, we discussed (1) the mechanisms of resistance to some of the most commonly used antimicrobial agents in the treatment of S. aureus: methicillin, vancomicyn and quinolon...

By Jovan Orlović, Biljana Miljković-Selimović, Marina Dinić, Ljiljana Ristić

Statins are drugs that are well tolerated, but considering their extensive use, there are still concerns regarding their safety. Knowledge of patients about the side effects of statins has not been adequately studied, although timely recognition of the AES is of vital importance for improving the quality of patient care and reducing morbidity and s...

By Valentina Opančina, Slobodan Janković, Gordana Stanić, Miljan Opančina

According to the definition, idiopathic intracranial hypertension (IIH) is a pathological state characterized by an increase in intracranial pressure; however, there are no obvious intracranial pathological processes. The pathophysiology of this disorder is not clear, although there are many reports related to it. We present an overview of possible...

By Srdjan Ljubisavljević, Jasna Zidverc Trajković

Topical anesthetic eye drops are used extensively for ophthalmic examinations but self-treatment and non-technical removal of foreign bodies using tetracaine drops can be hazardous. The present study intended to determine the inadmissible uses of anesthetic tetracaine eye drops, manner of drug obtaining and likelihood of the ocular complications in...

By Ebrahim Shirzadeh, Nematullah Shomoossi, Hasan Abdolahzadeh

Insulin resistance and β-cell function impairment play a role in the pathogenesis of type 2 diabetes (T2DM). Insulin signaling is inhibited by fetuin-A, an abundant plasma protein. Fetuin-A is also a candidate marker of the T2DM risk. This case-control study aimed to determine whether fetuin-A serum level is related to insulin resistance, &bet...

By Shatha Rouf Moustafa

The aim of this study was to investigate the possible potential of preschool staff through a newly designed questionnaire and evaluate their role in the prevention of early childhood caries (EEC) in Serbia where extremely high prevalence of this preventable disease was recorded.We preformed a cross-sectional study of 268 preschool staff using speci...

By Danijela Jakšić-Gvozdić, Slobodan M. Janković, Danka Pajović, Sandra Vidojević, Srđan Stefanović, Jasmina R. Milovanović

In recent years, results obtained from different studies with large cohorts have revealed a bond between the presence of extensive lymphocytic infiltration and favourable prognostic associations in the early-stage of breast cancer (BC) and high response rates to neoadjuvant chemotherapy. Examiners used tumors from large cohorts of patients who took...

By Ana Cvetanović, Slađana Filipović, Nikola Živković, Miloš Kostić, Svetislav Vrbić, Ivica Pejčić

The pathophysiology of periapical lesions (PLs) is under control of pro-inflammatory and anti-inflammatory (mainly immunoregulatory) cytokines. We have recently established mesenchymal stem cells (MSCs) from PLs and showed their suppressive effects on the production of proinflammatory cytokines from PLs inflammatory cells (ICs). In this work we stu...

By Milan Marković, Sergej Tomić, Jelena Djokić, Miodrag Čolić

Milk contains plenty of enzymatic and non-enzymatic antioxidant components that probably account for the vital antioxidant protection of the infants at early stages of life against the development of complications induced by oxygen free radicals. Indigenous milk enzymes play a key role in regulating lactogenesis, including active involution of mamm...

By Jelena Živković, Slavica Sunarić, Nataša Trutić, Marko Denić, Gordana Kocić, Tatjana Jovanović