Rutin (quercetin-3-O-rutinoside) is one of the most abundant bioflavonoids with various biological and pharmacological activities. Considering the ubiquitous presence of Mg(II) and Ca(II) ions in biological systems we decided to investigate their influence on the autoxidation of rutin in weakly alkaline aqueous solutions. Changes in UV-Vis spectra ...

By Slavoljub C. Živanović, Ružica S. Nikolić, Goran M. Nikolić

Combating Staphylococcus aureus (S. aureus) infections using antibacterial drugs is actually an ongoing effort to overcome resistance mechanism of this microorganism. In this paper, we discussed (1) the mechanisms of resistance to some of the most commonly used antimicrobial agents in the treatment of S. aureus: methicillin, vancomicyn and quinolon...

By Jovan Orlović, Biljana Miljković-Selimović, Marina Dinić, Ljiljana Ristić

Statins are drugs that are well tolerated, but considering their extensive use, there are still concerns regarding their safety. Knowledge of patients about the side effects of statins has not been adequately studied, although timely recognition of the AES is of vital importance for improving the quality of patient care and reducing morbidity and s...

By Valentina Opančina, Slobodan Janković, Gordana Stanić, Miljan Opančina

Topical anesthetic eye drops are used extensively for ophthalmic examinations but self-treatment and non-technical removal of foreign bodies using tetracaine drops can be hazardous. The present study intended to determine the inadmissible uses of anesthetic tetracaine eye drops, manner of drug obtaining and likelihood of the ocular complications in...

By Ebrahim Shirzadeh, Nematullah Shomoossi, Hasan Abdolahzadeh

Leech therapy is likely to cause symptomatic relief in migraine headache sufferers, but there is little clinical data in this field. This study aimed to investigate the effectiveness of leech therapy in the management of migraine headaches. This is a quasi-experimental pilot study with a three-month post-treatment follow-up. Twenty-six patients wit...

By Mahmoud Bakhshi, Babak Jalalian, Maryam Valian, Saeide Shariati, Tahere Saeidi, Hossein Ranjbar

Peutz-Jeghers syndrome (PJS) is a rare genetic disorder with autosomal-dominant pleiotropic inheritance, variable penetrance and characteristic signs of the disease that predisposes persons to increased risk of developing cancer, particularly in the gastrointestinal tract and the breast. Due to genetic nature of disease, in the familial Peutz-Jeghe...

By Marijola Mojsilović, Vuka Katić, Ivan Ilić, Biljana Radovanović, Bratislav Petrović, Miodrag Lazić, Marijana Krstić

The pathophysiology of periapical lesions (PLs) is under control of pro-inflammatory and anti-inflammatory (mainly immunoregulatory) cytokines. We have recently established mesenchymal stem cells (MSCs) from PLs and showed their suppressive effects on the production of proinflammatory cytokines from PLs inflammatory cells (ICs). In this work we stu...

By Milan Marković, Sergej Tomić, Jelena Djokić, Miodrag Čolić

The aim of the paper was to investigate the tissue response to the implantation of "Endomethasone" (Septodont) in artificially prepared defect in the rat mandible. Sixteen Wistar male rats were used for the experiment. After anesthesia, a defect between the midline and the mental foramen of the left mandible was made (diameter 1.4 mm, 1.6 mm depth)...

By Marija Nikolić, Jovanka Gašić, Aleksandar Mitić, Jelena Popović, Aleksandra Radovanović, Radomir Barac

For more than three decades, assisted reproductive techniques (ART) have been used as effective treatments to overcome infertility. Since then, numerous studies have been focused on different aspects of long-term health and development of children born after assisted conception. The aim of this paper is to summarize new data on multiple pregnancy a...

By Milena Milićević, Srećko Potić

Milk contains plenty of enzymatic and non-enzymatic antioxidant components that probably account for the vital antioxidant protection of the infants at early stages of life against the development of complications induced by oxygen free radicals. Indigenous milk enzymes play a key role in regulating lactogenesis, including active involution of mamm...

By Jelena Živković, Slavica Sunarić, Nataša Trutić, Marko Denić, Gordana Kocić, Tatjana Jovanović