The aim of this study was to analyze the reasons why the guidelines for post-splenectomy vaccination are not being followed. Considering that vaccination reduces the risk of overwhelming post-splenectomy infection, it is important to determine the reasons for inadequate vaccination after splenectomy. Our research was a qualitative study based on in...

By Marko Tanasković, Bozidar Odalović, Slobodan Janković, Nedim Hamzagić

Considering a large number of pathogen factors that enable high virulence of a microorganism such as Staphylococcus aureus (S. aureus), it is essential to see them through the continuous adaptation to the newly acquired mechanisms of the host immune response and efforts to overcome these, allowing the bacteria a perfect ecological niche for growth,...

By Biljana Miljković-Selimović, Marina Dinić, Jovan Orlović, Tatjana Babić

Salicylic acid is a phytochemical with beneficial effects on human well-being. Salicylic acid is a phenolic compound and is present in various plants where it has a vital role in protection against pathogenic agents. Natural sources include fruits, vegetables and spices. The most famous and defined effect of salicylic acid is prostaglandin synthesi...

By Pavle Randjelović, Slavimir Veljković, Nenad Stojiljković, Dušan Sokolović, Ivan Ilić, Darko Laketić, Dušica Randjelović, Nebojša Randjelović

In recent years, there has been a steady increase in the prevalence of allergic diseases. Allergic immune response represents a complex network of cellular events involving numerous immune cells and mediators. It represents the interaction of innate and acquired immune response. The key role in the immune cascade is taken by histamine, a natural co...

By Nikola Stojković, Snežana Cekić, Milica Ristov, Marko Ristić, Davor Đukić, Maša Binić, Dragan Virijević

Presently, there is very little data on the impact of nicotine and other components of tobacco smoking on the outcome of radioiodine therapy (RIT) in Graves’ disease (GD). Thus, this study was aimed to analyze a possible impact of cigarette smoking on the effect of radioiodine therapy in the patients with Graves’ disease. The study incl...

By Vladan Sekulić, Milena P. Rajić, Marina Vlajković, Slobodan Ilić, Miloš Stević, Ivana Mišić, Milan Božinović

The English language is undoubtedly lingua franca of contemporary globalised world. Besides its widespread use in official communication among different countries, it has also huge impact within the borders of one country as well. Taking into account the fact that nowadays it represents the basic communicative tool in the field of medical science i...

By Nataša Milosavljević, Zorica Antić

Many of the children referred to the emergency complain of head trauma. Children usually require sedition to reduce their failure and fear because of high activity and fear of performing computed tomography (CT). Dexmedetomidine and Midazolam belong to short-acting drugs for this purpose. This study aimed to compare the effect of the above mentione...

By Adel Hosseini, Shamila Noori, Abolfazl Mostafavi, Ali Sharami, Seyyed Abbas Hashemi, Hojjat Derakhshanfar, Farzad Bozorgi

The sequence of precursor lesions for squamous cell carcinoma may be hyperplasia-metaplasia-dysplasia-carcinoma in situ. The aim of this study was to perform a karyometric analysis of squamous metaplasia, moderate dysplasia and squamous cell lung carcinoma. Bronchoscopic biopsies of normal mucosa in chronic bronchitis patients (n = 10), squamous me...

By Žaklina Mijović, Zoran Pešić, Nikola Živković, Tijana Denčić, Ana Ristić Petrović, Slavica Stojnev

In search for new and promising coumarin compounds as HIV-1 integrase inhibitors, chemoinformatic methods like quantitative structure-activity relationships (QSAR) modeling and molecular docking have an important role since they can predict desired activity and propose molecule binding to enzyme. The aim of this study was building of QSAR models fo...

By Jovana Veselinović, Aleksandar Veselinović, Andrey Toropov, Alla Toropova, Ivana Damnjanović, Goran Nikolić

Isoform 2 of calsequestrin (CASQ2) is the main calcium-binding protein of sarcoplasmic reticulum (SR), expressed both in cardiac and in skeletal muscles. CASQ2 acts as an SR calcium (Ca2+) sensor and regulates SR Ca2+ release via interactions with triadin, junctin, and the ryanodine receptor. Various mutations of the csq2 gene lead to altered Ca2+ ...

By Rigers Bakiu