In many physiological processes, peptides play a critical role as neurotransmitters, hormones, antibiotics, etc. They have research importance in fields such as immunology, pharmacology, neuroscience and cell biology. There are many approaches for immunotherapies: some of them use the peptides as important components of chimeric molecules for immun...

By Stefan Dačić, Dragica Simonović Dačić, Goran Radičević, Aleksandar Mitić, Goran Tošić, Ivan Ristić, Stefan Veličković

Numerous comorbidities are frequently associated with asthma and may influence the clinical expression and severity of asthma. The aim of our study was to determine the presence and prevalence of other diseases in children with asthma, both of allergic and non-allergic origin. The study included 974 non - hospital patients, of whom 669 had asthma, ...

By Sanja Dimitrijević, Snežana Živanović, Ljiljana Šaranac

Obsessive-compulsive disorder (OCD) is defined by the presence of either obsession or compulsion that is severe enough to be time consuming or to cause marked distress or significant impairment. At some point during the course of the disorder, the person recognizes that the obsessions and compulsions are excessive or unreasonable. Twenty-one p...

By Lydia Sushevska, Nichola Olumchev, Mirjana Saveska

Perforation of peptic ulcer (PPU) is the most frequent complication of peptic ulcer disease. PPU is a serious complication which demands urgent diagnostic procedures, reanimation and surgical intervention.  The aim of this study was to establish the frequency of PPU, diagnostic and therapy procedures, time and kind of surgical methods, as well...

By Ivana Đorđević, Aleksandar Zlatić, Irena Janković

Abdominal aortic aneurysm (AAA) is a complex disease defined as a pathologic dilatation of the infrarenal aorta that is often accompanied by significant superimposed atherosclerosis, inflammation and thrombosis. AAAs are a significant cause of morbidity and mortality in the United States and worldwide. While some patients may present with lower bac...

By Philip Tsao, Ivana Burazor

The geriatric population i.e. the elderly population is comprised of people older than 65, or, according to some authors, older than 75, which is relative, given the fact that there is often a  mismatch between an individual’s biological age and chronological age. Aging is a rather complex process during which various changes occur ...

By Tatjana Pejčić, Ivanka Đorđević, Ivana Stanković, Desa Nastasijević Borovac, Tatjana Rađenović Petković

Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral developmental disorder that is usually diagnosed in children, with the appearance of symptoms up to seven years. The diagnosis was twice more frequently confirmed in boys than in girls. ADHD is characterized by symptoms of inattention and/or impulsiveness and hyperactivity, which ...

By Lydia Sushevska, Nicholas Olumchev, Mirjana Saveska, Hadzhihamza Kadri

Coronary computed tomography angiography (CTA) is the first non-invasive imaging technique that allows the evaluation of the lumen and walls of the coronary arteries. The sensitivity in defining significant stenosis (>50% caliber reduction) is 93% for the evaluation of single vessels. This is a method for determination of the so-called Calcium s...

By Dejan Hristov, Marina Deljanin Ilić, Katarina Marković, Sanja Stojanović

Cerebral cavernous malformations (CCMs) are the most common vascular malformations in the brain, and occur at a rate of approximately 0.6 per 100.000 people. Recognized as familial or sporadic cases, CCMs are characterized as single or multiclusters of enlarged capillary-like channels with a single layer of endothelium and without intervening brain...

By Anuška V. Anđelković

The aim of this study is to present the importance of pharmacologic therapy in an early prevention of bleeding and rebleeding from the oesophageal varices in patients with portal hypertension.Three hundred and fifteen patients with liver cirrhosis have been evaluated and diagnosed in the University Clinic of Gastroenterohepatology. In the evaluatio...

By Nenad Joksimović, Vladimir Andreevski, Magdalena Genadieva, Meri Trajkovska