Introduction/Aim. Epidermal growth factor receptor (EGFR) is one of the key tumor markers of non-small cell lung cancer (NSCLC) and a guideline for the choice of therapeutic procedures. The research aims to evaluate the methods used in the investigation of EGFR variants in NSCLC cell lines and combined research (NSCLC cell lines and patient samples...

By Jovana Todosijević-Jovanović, Jasmina Obradović, Vladimir Jurišić

Introduction. Patients with a fluent type of aphasia have semantically poor discourse, which is often uninformative for the interlocutor, having consequences for their daily life. One of the treatment methods used in clinical practice is the semantic feature analysis (SFA). The aim of this study was to determine the impact of this treatment method ...

By Tanja Milovanović, Mile Vuković, Sindi Mitrović

Introduction. Acute intermittent porphyria is a rare metabolic disorder of the hem biosynthetic pathway that can cause severe neurological symptoms involving the central, autonomic and peripheral nervous system. Diagnosis may be delayed due to variable symptoms that can mimic other diseases. Case report. A 23-year-old woman with abdominal pain, con...

By Stefan Todorović, Gordana Đorđević, Andrija Rančić, Dejan Aleksić

Introduction/Aim. The internal carotid artery (ICA) is a paired artery that primarily supplies the anterior two-thirds of the brain, the pituitary gland, the eye structures, and some other cranial structures. The ICA variations or abnormalities have been more or less described; especially, bilateral ICA hypoplasia (ICAH) was a very rare description...

By Ljiljana Vasović, Ana Mrkaić, Miracle Wangsuwana, Dimitrije Đorđević, Milena Trandafilović

Introduction/Aim. Microencapsulation technology can be used for the protection of Alpha-tocopherol from degradation in unfavorable environments and enhancement of bioavailability and shelf-life of vitamin E. The aim of this study was the synthesis and characterization of alginate microparticles for the oral delivery of a-tocopherol. Methods. Four d...

By Milja Živković, Ana Barjaktarević, Marina Tomović, Anđela Uštević

Introduction/Aim. Chronic apical periodontitis represents dynamic continuation of the presence of endodontic infection in the root canal system of the tooth, when the innate and acquired immune responses are activated and various cells and inflammatory mediators are recruited, which cause the consequent destruction of periapical tissues and the dev...

By Jelena Popović, Tatjana Cvetković, Tanja Džopalić, Aleksandar Mitić, Marija Nikolić, Radomir Barac, Nenad Stošić, Antonije Stanković

Introduction/Aim. Adrenal incidentalomas (AIs) are defined as tumours revealed during imaging procedures of abdomen or abdominal laparotomy, performed in patients without previous suspicion for adrenal disease. This study was conducted to evaluate morphological and functional features of AIs seven years after the initial diagnosis. Patients and met...

By Danijela Radojković, Milica Pešić, Milan Radojković, Saša Radenković, Vojislav Ćirić, Ivan Ilić, Miloš Stević

Introduction/Aim. Agreement or disagreement of inflammatory parameters becomes important for making diagnosis when disparate values are encountered in a patient with suspected sepsis. The aim of our study was to test the agreement between the four commonly used tests for diagnosing systemic infection: white blood cell count (WBC), serum levels of C...

By Marija Bulić, Marija Anđelković, Marina Mitrović, Marijana Stanojević-Pirković, Marina Kostić, Slobodan Janković, Jovan Luković, Violeta Mladenović, Ivana Nikolić

Background/Aim. Incremental cost/effectiveness ratio (ICER) of many drugs for rare diseases is often much higher that the accepted cost/effectiveness threshold for reimbursement, primarily due to their extremely high prices, raising the question of their availability. The aim of this article was to review necessary adjustments of methods used for c...

By Branislava Raičević, Slobodan Janković

Introduction. Collision tumors occur when two tumors of different histological origin develop simultaneously at the same site, such as sarcoma and carcinoma combinations, carcinoma and lymphoma combinations, or others. Notably, collision tumors are less common in the lungs compared to other organs. Case report. A 65-year-old woman with a history of...

By Džemila Alić, Marina Marković, Slobodanka Mitrović, Milena Ilić, Ajtana Bajrović, Jelena Savić, Marija Spasojević, Dalibor Jovanović