Chronic apical periodontitis represents dynamic continuation of the presence of endodontic infection in the root canal system of the tooth, when the innate and acquired immune responses are activated and various cells and inflammatory mediators are recruited, which cause the consequent destruction of periapical tissues and the development of periap...

By Jelena Popović, Tatjana Cvetković, Tanja Džopalić, Aleksandar Mitić, Marija Nikolić, Radomir Barac, Nenad Stošić, Antonije Stanković

Epidermal growth factor receptor (EGFR) is one of the key tumor markers of non-small cell lung cancer (NSCLC) and a guideline for the choice of therapeutic procedures. The research aims to evaluate the methods used in the investigation of EGFR variants in NSCLC cell lines and combined research (NSCLC cell lines and patient samples) in the last deca...

By Jovana Todosijević-Jovanović, Jasmina Obradović

Microencapsulation technology can be used for the protection of Alpha-tocopherol from degradation in unfavorable environments and enhancement of bioavailability and shelf-life of vitamin E. The aim of this study was the synthesis and characterization of alginate microparticles for the oral delivery of a-tocopherol. Four different formulations of Al...

By Milja Živković, Ana Barjaktarević, Marina Tomović, Anđela Uštević

Understanding the mechanisms and classification of drug interactions can significantly reduce the occurrence of adverse effects and improve compliance. The drug selection process is complex and involves the patient's individual condition, physiological status, use of other drugs, and co-existing illnesses. It is particularly challenging to choose a...

By Sanja Stanković, Nikola Stefanović, Maša Jović, Radmila Veličković-Radovanović

During the SARS-CoV-2 pandemic, there was a significant number of cases accompanied by thrombosis. The precise pathophysiological mechanism remains unclear. The importance of the fibrinolytic mechanism in maintaining physiological hemostasis led us to explore its potential contribution to COVID-19-induced thromboembolism. This study aimed to identi...

By Igor Spasić, Dejan Dobrijević, Biljana Vučković

Introduction/Aim. Keloid is a benign proliferative lesion of the dermal connective tissue. It is a challenging clinical problem, despite multiple therapies reported until now. The aim of the study was to determine the efficacy of intralesional methotrexate in the treatment of keloid in comparison to intralesional triamcinolone. Methods. This is an ...

By Mohammed Abbas, Athraa Ali, Zaid Al-Attar

There is a cause-and-effect relationship between stress, sleep disorders and emotional brain function. Insufficient quality and duration of sleep can trigger or exacerbate anxiety in an individual. The study aims to assess the scores for sleep disorders and the level of stress depending on typological features of state and trait anxiety in patients...

By Anastasiia Zhyvotovska, Dmytro Boiko, Lesya Bodnar, Yurii Kozar, Yanina Martynenko, Rustam Isakov

The postpartum period is considered a period of increased risk of developing bipolar affective disorder (BDII) type II. According to the available data, postpartum BDII is a highly neglected area of observation, with negative consequences for mothers, offspring, and the family as a whole. The paper describes the case of a patient with symptoms of a...

By Jelena Stojanov, Olivera Žikić, Miodrag Stanković

Acute intermittent porphyria is a rare metabolic disorder of the hem biosynthetic pathway that can cause severe neurological symptoms involving the central, autonomic and peripheral nervous system. Diagnosis may be delayed due to variable symptoms that can mimic other diseases. A 23-year-old woman with abdominal pain, constipation, progressive deve...

By Stefan Todorović, Gordana Đorđević, Andrija Rančić, Dejan Aleksić

The internal carotid artery (ICA) is a paired artery that primarily supplies the anterior two-thirds of the brain, the pituitary gland, the eye structures, and some other cranial structures. The ICA variations or abnormalities have been more or less described; especially, bilateral ICA hypoplasia (ICAH) was a very rare description that inspired aut...

By Ljiljana Vasović, Ana Mrkaić, Miracle Wangsuwana, Dimitrije Đorđević, Milena Trandafilović