Biologics (biopharmaceuticals) present new promising therapies for many diseases such as cancers, chronical inflammatory diseases and today's biggest challenge - COVID-19. Today, most biologics have been synthetized using modern methods of biotechnology, in particular DNA recombinant technology. Current pharmaceutical forms of protein/peptide bioph...

By Sanja Stanković, Marija Tasić-Kostov

Oxidative stress and resulting lipid peroxidation are involved in numerous pathological conditions. For this reason, the role of antioxidants attracts attention and the radical-scavenging capacity of many natural and synthetic supplements and drugs has been extensively evaluated. In the present study, seven N,N'-disubstituted benzimidazole-2-thione...

By Jelena Lazarević, Jelena Zvezdanović, Neda Anastassova, Anelia Mavrova, Denitsa Yancheva, Andrija Šmelcerović

Pseudothrombocytopenia induced by ethylenediaminetetraacetic acid is a rare phenomenon caused by autoantibodies against platelet membrane with overall prevalence of 0.1% in the general population. This phenomenon is an in vitro artifact and with different anticoagulant used, the patient had the physiological platelet count. This case is a report of...

By Dejan Dobrijević, Nataša Kaćanski-Rađenović, Jovanka Kolarović

The aim of the study was to examine the relationship between noise exposure and the incidence of arterial hypertension as well as the relationship of noise annoyance and noise sensitivity with hypertension. A cross-sectional questionnaire survey was performed on 911 adult residents of Niš, Serbia, of whom 388 were men (42.6%) and 523 women (...

By Ljiljana Stošić, Dušica Stojanović, Konstansa Lazarević

FH is an autosomal dominant disease of lipid metabolism. Hypercholesterolemia, xanthomas, and death from early coronary artery disease (CAD) are common in this disease due to a mutation in the LDLR, Apo-B100 or PCSK9 genes. A 4-year-old male patient with a very rare heterozygous c.1730G > C (p.Trp577Ser) variation in exon 12 of the low-density l...

By Mustafa Doğan, Mehmet Koksal, Recep Eroz

Varicella zoster virus is a highly infectious a-herpesvirus, pathogenic only to humans. The primary infection of varicella zoster virus causes chickenpox, which is contagious and primarily infects children and adolescents in India. Following the primary infection, the virus remains dormant in sensory root ganglia. Activation of the dormant virus in...

By Varshini Marimuthu, Dinakar Jayakumar, Gowri Shanmugasundaram

The paper was aimed at determining the CCL2/MCP-1 level in patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and mediastinum. The study involved 46 patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and 12 healthy volunteers. The level of pa...

By Mariia Faustova, Oleksandr Nazarchuk, Dmytro Dmytriiev, David Avetikov, Galina Loban, Yuliana Babina, Maiia Ananieva

Neutrophil-lymphocyte ratio (NLR) is one of the laboratory biomarkers used in clinical practice to predict severity and mortality of acute pancreatitis (AP), however, there is currently insufficient information about the changes of NLR in the dynamics in relationship with other clinical and laboratory data. To assess the relationship between NLR va...

By Tetiana Formanchuk, Hryhoriy Lapshyn, Mariya Pokidko, Andrii Formanchuk, Igor Vovchuk

The objective of this narrative review was to describe the versatile links between mental status and sleep in patients with Parkinson's disease. We searched randomized controlled studies, observational studies, meta-analyses, systematic reviews, and case reports written in English in PubMed during 2015 - 2021. Additionally, to ensure the completene...

By Anastasiia Shkodina, Tymur Iengalychev, Kateryna Tarianyk, Dmytro Boiko, Nataliia Lytvynenko, Andrii Skrypnikov

Chemotherapy may cause various nail damages, including chromonychia, melanonychia, onycholisis, and onychomadesis. Melanonychia is characterized by melanin-derived brown-to-black nail pigmentation. It may occur as a result of nail matrix melanocytic activation or melanocytic hyperplasia, and nail invasion by melanin-producing pathogens. We present ...

By Ivan Petković