Inflammatory bowel disease (IBD) is a significant cause of morbidity and disability in pediatric patients, characterized by chronic intestinal inflammation. Biologic therapies, such as adalimumab and infliximab, are widely used for induction and maintenance of remission. Therapeutic drug monitoring (TDM) enables individualized treatment by optimizi...

By Jasmina Katanić, Dejan Dobrijević, Mirjana Stojšić

Nizon-Isidor syndrome (NIZIDS) is a rare genetic disorder associated with mutations in the MED12L gene and is usually characterized by a distinctive facial appearance, neurodevelopmental delay, autism spectrum disorders (ASD), and chronic gastrointestinal symptoms (GIS). In this case report, we emphasize the importance of early evaluation of geneti...

By Mehmet Semih Demirtaş, Yakup Köylü

Older edentulous adults often rely on mucosa-supported complete dentures (CDs) due to limitations that preclude implant therapy. Although an adequate retention of maxillary CD is essential for functional efficiency, compression of the palatal mucosa during impression making may compromise palatal mucosal microcirculation during denture wear. T...

By Petar Tekić, Stefan Vulović, Marija Milić, Marko Igić, Milena Kostić, Aleksandra Popovac, Ivica Stančić, Aleksandra Milić Lemić

Preterm prelabor rupture of membranes (PPROM) is a major cause of neonatal morbidity and mortality. Placental Protein 14 (PP14), a glycodelin glycoprotein, has emerged as a potential biomarker for the diagnosis of PPROM. The study aimed to evaluate the diagnostic accuracy of PP14 in detecting fetal membrane rupture. This case-control study was cond...

By Alaa Ali Rahi, Miami Abdul Hassan Ali

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects the reproductive, metabolic, and psychological health of women of reproductive age. Conventional therapies for PCOS primarily focus on symptom management; however, their associated side effects have led many women to explore complementary approaches. This review aimed to ...

By Gala Žarković, Vladimir Jakovljević, Saša Raičević, Angela Ćorić, Rosa Čukić Ćorović, Nikola Jović, Jovana Joksimović Jović

Artificial intelligence (AI) represents a global phenomenon changing all spheres of human life. Biomedical engineering is no exception, as many AI systems are applied to biomedical engineering inventions. The European Union has enacted the new EU AI Act, one of the world’s first laws on AI. The main topic of this research is to examine what c...

By Srdjan Djordjević, Nikola Ivković, NIkola Milosavljević

Halogenated boroxine is an important enzyme inhibitor with potential applications in cancer therapy. This study aimed to evaluate its effects on hematological parameters in rats in vivo and creatine kinase activity in vitro. Halogenated boroxine, administered either intraperitoneally (IP) or orally, induced route-dependent changes in hematological ...

By Safija Herenda, Elma Hasković, Muhamed Fočak, Alem Bekan, Sabina Prevljak, Nenad Vanis, Mirza Halimić, Alen Džubur, Edhem Hasković

Artificial intelligence (AI)-assisted digital mental health interventions are being increasingly discussed as a potential strategy for improving access to psychological support among adolescents with anxiety symptoms and anxiety disorders. Their possible advantages include flexible availability, reduced barriers to help-seeking, psychoeducation, sy...

By Aleksandra Stojanović, Miodrag Stanković, Aleksandra Ristić

Laparoscopic cholecystectomy is the standard treatment for gallbladder disease; the carbon dioxide pneumoperitoneum required for the procedure may transiently affect liver function. The aim is to examine the evaluation of the impact of different levels of intra-abdominal pressure (IAP) and ASA score on postoperative liver biochemical parameters. A ...

By Mladen Kasalović, Gojko Igrutinović, Saša Dimić, Nikola Miljković, Aleksandar Jakovljević, Zlatan Elek, Marija Milanović

Caspase-1 (CASP1) is an integral part of the inflammasome, and rheumatoid arthritis (RA) is a complex, progressive, chronic inflammatory autoimmune disease. The present study aimed to investigate two aspects of RA: i) the association of CASP1 gene polymorphisms with susceptibility to RA; and ii) the prevalence of temporomandibular joint (TMJ) invol...

By Wasan Lafta Abdullah, Ali Hussein Al-Hafidh, Batool Hassan Al-Ghurabi, Abbas Fadhil Al-Hashimy