Summary The aim of this study was to investigate the exogenous agmatine influence on nitrosative and oxidative stress parameters in acute phase of multiple sclerosis (MS) experimental model, experimental autoimmune encephalomyelitis (EAE). EAE was induced by subcutaneous injection of myelin basic protein (50 μg per animal). Sprague-Dawley ...

By Ivana Stojanović, Srđan Ljubisavljević, Ivana Stevanović, Slavica Stojnev, Radmila Pavlović, Dušan Sokolović, Aleksandar Petrović, Dušica Pavlović, Tatjana Cvetković

Summary The aim of the paper was to show the diagnostic and therapeutic approaches to a patient suffering from osteomalacia, as well as differential diagnosis with osteoporosis. Osteomalacia (OM) is a metabolic disease of bones which appears as a result of defective mineralization of newly formed bone matrix in adults. Diagnosis of diseas...

By Nela Živković, Sonja Stojanović

Summary Isoform 2 of calsequestrin (CASQ2) is the main calcium-binding protein of sarcoplasmic reticulum (SR), expressed both in cardiac and in skeletal muscles. CASQ2 acts as an SR calcium (Ca2+) sensor and regulates SR Ca2+ release via interactions with triadin, junctin, and the ryanodine receptor. Various mutations of the csq2 gene lead to a...

By Rigers Bakiu

Summary Bone marrow involvement is rare in patients with Hodgkin lymphoma (HL). Its incidence varies with respect to risk factors from 4% to 14%. Low risk patients do not need trephine biopsy according to some research. In the era of positron emission tomography/computed tomography (PET/CT) staging prior to therapy, the role of trephine biopsy...

By Ivan Petković, Miljan Krstić, Slavica Stojnev, Ivica Pejčić, Svetislav Vrbić

Summary Reproductive health implies that people are able to have a responsible, satisfying and safe sex life and that they have the capability to reproduce and the freedom to decide about it. It is directly conditioned by social, cultural and behavior factors. One in every five people in the world is an adolescent, and 85% of them live in...

By Olivera Radulović, Slađana Babić, Milena Veljković, Ana Stefanović, Čedomir Šagrić, Katarina Bulatović

SUMMARY Medicinal herbs and their mixtures, which are widely used for prevention and treatment of some disease, can also present health risks due to the presence of toxic metals such as Pb and Cd. The application of different agrotechnical practices during plant growing season, as well as the process of circulation of substances in nature, may...

By Biljana Kaličanin, Dragan Velimirović, Ivana Arsić, Sofija Đorđević

SUMMARY By introduction of all-trans retinoic acid (ATRA) in de novo acute promyelocytic leukemia (APL) an revolution in therapy of this disease has been made. The rate of molecular complete remissions (CR) have been doubled compared to conventional chemotherapy with anthracyclines ranging from 90% to 95%. Consolidation therapy is required in ...

By Ivan Petković, Ivica Pejčić, Svetislav Vrbić

Summary Anal sphincter injuries are rare and usually related to obstetric injuries. Other more frequent causes of a violent injury of the anal muscles (including the rectum) are war injuries, violent civil injuries, iatrogenic injuries during surgeries, sexual injuries and accidental injuries. Accidental injuries are extremely rare and, searching M...

By Momčilo Stošić

SUMMARY The aim of the paper was to determine the disease trends and characteristics of anti-HCV antibody carrier status for the purpose of better prevention and disease control. The materials used were annual reports, reports of diseases and deaths from infectious diseases, and epidemiological surveys of the Public Health Institute Niš i...

By Marina Kostić, Biljana Kocić, Lidija Popović Dragonjić

Summary Skin aging is a dynamic process that occurs due to chronological and photo-aging caused by the influence of external factors, especially ultraviolet-UV radiation. Cumulative oxidative stress, formation of free radicals and their adverse effects on biological systems in the skin cells is a common mechanism of both skin aging processes. ...

By Dragana Stojiljković, Dušica Pavlović, Ivana Arsić