Currently, there is no classification reflecting the severity of complicated intra-abdominal infections (cIAIs). Therefore, we aimed to create one and facilitate the prognostic assessment of cIAIs in clinical practice. This was a single-center study conducted at a University Hospital Stara Zagora including 140 patients with cIAIs. Retrospectively, ...

By Evgeni Dimitrov, Georgi Minkov, Emil Enchev, Yovcho Yovtchev

The incidence of acute myocardial infarction (AMI) is declining in developed countries due to better prevention and more effective treatment of risk factors, however, the proportion of younger patients with AMI is increasing. The aim of the research was to compare patients under the age of 45 years with acute myocardial infarction at a ten-year int...

By Danijela Đorđević-Radojković, Miodrag Damjanović, Svetlana Apostolović, Jelena Milošević, Dragana Stanojević, Goran Koraćević, Ružica Janković-Tomašević, Tomislav Kostić, Sonja Dakić, Jelena Cvetković, Jovana Šarić

Although COVID-19 is present in a milder form nowadays, systemic disorders caused by the virus lead to multiple organ malfunctions. Skin manifestations are the consequence of the disease itself but also the result of preventative measures taken to avoid the infection. They generally do not require pharmacotherapy except in severe cases. Depending o...

By Marija Tasić-Kostov

During the SARS-CoV-2 pandemic, there was a significant number of cases accompanied by thrombosis. The precise pathophysiological mechanism remains unclear. The importance of the fibrinolytic mechanism in maintaining physiological hemostasis led us to explore its potential contribution to COVID-19-induced thromboembolism. This study aimed to identi...

By Igor Spasić, Dejan Dobrijević, Biljana Vučković

Polypharmacy can increase the risk of side effects and cause adverse drug interactions with a significant impact on the course of the basic disease. The aim of the study was to determine the frequency of polypharmacy and examine its impact on the risk of drug-drug interactions in patients with rheumatoid arthritis (RA). The research was conducted i...

By Nikola Krstić, Nikola Stefanović, Milan Petronijević, Ivana Damnjanović

Acute intermittent porphyria is a rare metabolic disorder of the hem biosynthetic pathway that can cause severe neurological symptoms involving the central, autonomic and peripheral nervous system. Diagnosis may be delayed due to variable symptoms that can mimic other diseases. A 23-year-old woman with abdominal pain, constipation, progressive deve...

By Stefan Todorović, Gordana Đorđević, Andrija Rančić, Dejan Aleksić

There is a cause-and-effect relationship between stress, sleep disorders and emotional brain function. Insufficient quality and duration of sleep can trigger or exacerbate anxiety in an individual. The study aims to assess the scores for sleep disorders and the level of stress depending on typological features of state and trait anxiety in patients...

By Anastasiia Zhyvotovska, Dmytro Boiko, Lesya Bodnar, Yurii Kozar, Yanina Martynenko, Rustam Isakov

Introduction/Aim. Keloid is a benign proliferative lesion of the dermal connective tissue. It is a challenging clinical problem, despite multiple therapies reported until now. The aim of the study was to determine the efficacy of intralesional methotrexate in the treatment of keloid in comparison to intralesional triamcinolone. Methods. This is an ...

By Mohammed Abbas, Athraa Ali, Zaid Al-Attar

Patients with a fluent type of aphasia have semantically poor discourse, which is often uninformative for the interlocutor, having consequences for their daily life. One of the treatment methods used in clinical practice is the semantic feature analysis (SFA). The aim of this study was to determine the impact of this treatment method on the content...

By Tanja Milovanović, Mile Vuković, Sindi Mitrović

Herbs have been a vital renewable source of medicine throughout human history as a large proportion of the global population still depends on them for their health benefits. The increasing popularity of herbal supplements has raised an obvious concern about the overall safety and potential interaction with other drugs in situ. The intent was to spu...

By Mary Ologe, Yusuf Olalekan, Awodayo Adepiti, Olubunmi Atolani, Anoka Njan, Adedibu Tella, Ezekiel Iwalewa