Many markers are used to evaluate the prognosis in patients with acute myocardial infarction (AMI). Researches are focused on available markers with high sensitivity and specificity. The aim of our study was to evaluate the prognostic value of N-terminal pro brain natriuretic peptide (NT-proBNP) and its superiority compared with other prognostic ma...

By Rada Vučić, Vladimir Ignjatović, Olivera Andrejić, Katarina Čupić, Miodrag Srećković, Filipović Vučković, Marija Sekulić, Milan Dobrić, Jelena Rakočević

Multiple myeloma is a malignant plasma cell disorder characterized by clonal proliferation of abnormal plasma cells. Global five-year survival rates range from 60% to 70%, largely due to novel therapeutic strategies. In our country, conventional therapies remain standard, with monoclonal antibodies recently introduced for relapsed/refractory cases....

By Dragana Drašković, Goran Marjanović, Miodrag Vučić, Irena Ćojbašić

Splenic abscess is a very rare extra-intestinal complication of Salmonella infection in the post-antibiotic era with the incidence between 0.14% and 2%. It usually follows bacteremia due to varied etiologies such as trauma, infective endocarditis, intravenous drug abuse, immunodeficiency status (AIDS, diabetes mellitus). An 82-year-old woman presen...

By Milan Pantelić, Tamara Vučinić, Milica Stanucević, Miloš Dujović, Maša Pantelić

Ketorolac is a potent non-steroidal anti-inflammatory drug (NSAID) that can inhibit cyclooxygenase activity and prostaglandin synthesis, thereby reducing pain and inflammation. The aim of this study was to investigate the hepatorenal toxicity of ketorolac administration in adult male rats. Twenty-four adult male Wistar rats were randomly assigned t...

By Fatemeh Rashidi, Amir Noyani, Salma Omidi, Touraj Assadi

Glioblastomas (GBMs) are among the most vascularized human tumors and the presence of microvascular proliferation is one of the diagnostic hallmarks of these malignancies. The aim of the present study was to investigate the extent of vascularization and its relation to proliferative activity and the p53 status in GBMs. Tissue samples from 100 selec...

By Desanka Tasić, Irena Dimov, Miloš Kostov, Dragan Dimov

Multiple sclerosis (MS) is a chronic, autoimmune demyelinating disease of the central nervous system. The association of vitamin D deficiency, sun exposure, and higher incidence of multiple sclerosis has been known for long, and a number of studies have confirmed anti-inflammatory and neuroprotective properties of vitamin D. Vitamin D receptor (VDR...

By Lazar Bajić, Dejan Savic, Nikola Krstić, Ana Andrejević, Andrija Rančić, Miljana Mladenović, Tatjana Jevtovic Stoimenov

Parkinson's disease (PD) is a chronic, neurodegenerative disorder that in certain stages can present a series of acute symptoms and signs, the development of which lasts several hours or days. Emergencies in PD can be a direct consequence of the pathophysiology of the disease or a secondary consequence of the administration of antiparkinsonian drug...

By Jelena Stamenović, Vuk Milošević, Vanja Đurić

Restoring the morphological and functional integrity of damaged or lost teeth and replacing them with suitable materials remains a significant challenge in modern dentistry. A continuous development of new restorative materials aims to improve mechanical properties, aesthetic outcomes, and longevity of dental restorations, while minimizing adverse ...

By Ana Pejčić, Milena Kostić, Ivana Stankovic, Radmila Obradovic, Marija Bradic-Vasic, Marija Đorđević, Marko Igic, Nikola Gligorijević

The emergence of the COVID-19 pandemic has underscored the critical importance of accurate and reliable methods for the early detection and management of cases. Traditional approaches to COVID-19 diagnosis often rely on binary classification methods, which may limit their accuracy and robustness. In this study, we propose a novel approach that leve...

By Affaf Khaouane, Latifa Khaouane, Samira Ferhat, Salah Hanini

Artificial intelligence (AI) is reshaping personalized medicine by enabling earlier diagnosis, tailored therapies, and faster drug discovery. The aim of the paper was to synthesize current evidence on AI applications in precision healthcare and quantify their impact on diagnostics, therapeutic decision-making, and discovery. We conducted a systemat...

By Marko Kimi Milić, Šćepan Sinanović, Tatjana Kilibarda, Saša Bubanj